National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

GTPase KRas
Synonyms

K-Ras-2 p21

c-K-Ras Protein

GTPase KRas

p21 K-Ras Protein

K-Ras p21 Protein

K-Ras-2 Protein

K-Ras 2

K-Ras 2A

KRAS

KRAS2

Ki-Ras

c-K-Ras

c-Ki-ras

Definitions

GTPase KRas (189 aa, ~21 kDa) is encoded by the human KRAS gene. This protein is involved in the regulation of GTP metabolism and in signaling.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17383

code

C17383

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142800

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

Contributing_Source

CTRP

DEFINITION

GTPase KRas (189 aa, ~21 kDa) is encoded by the human KRAS gene. This protein is involved in the regulation of GTP metabolism and in signaling.

DesignNote

There are at least 2 isoforms of GTPase KRas called K-Ras4A and K-Ras4B. These osoforms differ in the C-terminal region which is encoded by two alternative exons (IVA and IVB). UniProt considers K-Ras4A the canonical isoform.

Display_Name

GTPase KRas

FULL_SYN

K-Ras-2 p21

c-K-Ras Protein

GTPase KRas

p21 K-Ras Protein

K-Ras p21 Protein

K-Ras-2 Protein

K-Ras 2

K-Ras 2A

KRAS

KRAS2

Ki-Ras

c-K-Ras

c-Ki-ras

label

GTPase KRas

Legacy Concept Name

p21_K-Ras_Protein

OMIM_Number

190070

Preferred_Name

GTPase KRas

prefixIRI

Thesaurus:C17383

Semantic_Type

Amino Acid, Peptide, or Protein

Enzyme

Swiss_Prot

P01116

UMLS_CUI

C0763464

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17388

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