National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Mecobalamin

Synonyms

Vitamin B12

METHYLCOBALAMIN

Methylcobalamin

Mecobalamin

Definitions

A synthetic and active form of vitamin B12 that can cross the blood brain barrier without biotransformation, that may be used to treat or prevent vitamin B12 deficiency and its complications. Upon administration, mecobalamin is able to replace endogenous vitamin B12, increase vitamin B12 levels and improve vitamin B12 deficiency. Vitamin B12 is necessary for hematopoiesis, neural metabolism, DNA and RNA production, and carbohydrate, fat, and protein metabolism. It improves iron functions in the metabolic cycle and assists folic acid in choline synthesis. Its metabolism is interconnected with that of folic acid.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173805

CAS_Registry

13422-55-4

code

C173805

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A synthetic and active form of vitamin B12 that can cross the blood brain barrier without biotransformation, that may be used to treat or prevent vitamin B12 deficiency and its complications. Upon administration, mecobalamin is able to replace endogenous vitamin B12, increase vitamin B12 levels and improve vitamin B12 deficiency. Vitamin B12 is necessary for hematopoiesis, neural metabolism, DNA and RNA production, and carbohydrate, fat, and protein metabolism. It improves iron functions in the metabolic cycle and assists folic acid in choline synthesis. Its metabolism is interconnected with that of folic acid.

FDA_UNII_Code

BR1SN1JS2W

FULL_SYN

Vitamin B12

METHYLCOBALAMIN

Methylcobalamin

Mecobalamin

label

Mecobalamin

NCI_Drug_Dictionary_ID

809084

Preferred_Name

Mecobalamin

prefixIRI

Thesaurus:C173805

Semantic_Type

Pharmacologic Substance

Vitamin

UMLS_CUI

C0065844

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C939

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