loading...| Preferred Name |
D(2) Dopamine Receptor |
|
| Synonyms |
DRD2 Receptor D(2) Dopamine Receptor Dopamine D2 Receptor DOPAMINE RECEPTOR D2 Dopamine Receptor D2 DRD2 |
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| Definitions |
D(2) dopamine receptor (443 aa, ~51 kDa) is encoded by the human DRD2 gene. This protein plays a role in dopamine binding, angiogenesis inhibition, and receptor signaling. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17292 |
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| ALT_DEFINITION |
An antigen encoded by the DRD2 gene and is involved in dopamine binding, angiogenesis inhibition, and receptor signaling. It can be considered as an autoantigen and is commonly associated with autoimmune encephalitic syndromes and neuropsychiatric abnormalities. |
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| code |
C17292 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66830 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61410 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142800 |
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| Contributing_Source |
CDISC CTRP |
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| DEFINITION |
D(2) dopamine receptor (443 aa, ~51 kDa) is encoded by the human DRD2 gene. This protein plays a role in dopamine binding, angiogenesis inhibition, and receptor signaling. |
|
| DesignNote |
Neurotransmission mediated by the Dopamine D2 Receptor (DRD2) plays a key role in the control of movement, in reward and reinforcement mechanisms in psychiatric disorders, and in the neuromodulation of appetitive behaviors. Acting through D2 dopamine receptors, dopamine specifically inhibits the vascular permeabilizing and angiogenic activities of VEGF by inducing endocytosis of VEGF receptor 2, preventing VEGF binding, receptor phosphorylation, and signaling. (OMIM) |
|
| Display_Name |
D(2) Dopamine Receptor |
|
| FULL_SYN |
DRD2 Receptor D(2) Dopamine Receptor Dopamine D2 Receptor DOPAMINE RECEPTOR D2 Dopamine Receptor D2 DRD2 |
|
| label |
D(2) Dopamine Receptor |
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| Legacy Concept Name |
Dopamine_Receptor-D2 |
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| OMIM_Number |
126450 |
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| Preferred_Name |
D(2) Dopamine Receptor |
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| prefixIRI |
Thesaurus:C17292 |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Receptor |
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| Swiss_Prot |
P14416 |
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| UMLS_CUI |
C3659270 |
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| subClassOf |