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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Urokinase-Type Plasminogen Activator | |
| Synonyms |
EC 3.4.21.73 urokinase-plasminogen activator U-Plasminogen Activator Urokinase-Type Plasminogen Activator Urinary Plasminogen Activator Plasminogen Activator, Urinary Plasminogen Activator, Urokinase Urokinase Plasminogen Activator u-plasminogen activator PLAU Urokinase u-PA uPA urokinase |
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| Definitions |
Urokinase-type plasminogen activator (431 aa, ~49 kDa) is encoded by the human PLAU gene. This protein plays a role in both cell surface receptor binding and the cleavage of plasminogen between Arg-580 and Val-581 to form the fibrinolytic enzyme plasmin. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17242 |
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| ALT_DEFINITION |
An enzyme that is made in the kidney and found in the urine. A form of this enzyme is made in the laboratory and used to dissolve blood clots or to prevent them from forming.
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| code |
C17242
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 |
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| Contributing_Source |
CTRP
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| DEFINITION |
Urokinase-type plasminogen activator (431 aa, ~49 kDa) is encoded by the human PLAU gene. This protein plays a role in both cell surface receptor binding and the cleavage of plasminogen between Arg-580 and Val-581 to form the fibrinolytic enzyme plasmin.
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| DesignNote |
Urokinase-type plasminogen activator is found in high and low molecular mass forms. Each form is comprised of two chains, A and B. The high molecular mass form contains a long chain A which is cleaved to yield a short chain A. (UniProt)
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| Display_Name |
Urokinase-Type Plasminogen Activator
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| FULL_SYN |
EC 3.4.21.73 urokinase-plasminogen activator U-Plasminogen Activator Urokinase-Type Plasminogen Activator Urinary Plasminogen Activator Plasminogen Activator, Urinary Plasminogen Activator, Urokinase Urokinase Plasminogen Activator u-plasminogen activator PLAU Urokinase u-PA uPA urokinase
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| label |
Urokinase-Type Plasminogen Activator
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| Legacy Concept Name |
Urokinase
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| NCI_META_CUI |
CL790344
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| OMIM_Number |
191840
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| Preferred_Name |
Urokinase-Type Plasminogen Activator
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| prefixIRI |
Thesaurus:C17242
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| Semantic_Type |
Amino Acid, Peptide, or Protein Enzyme
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| Swiss_Prot |
P00749
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| subClassOf |
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