National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Flortaucipir F-18
Synonyms

Fluorine F18 T807

FLORTAUCIPIR F-18

Fluorine-18 Labeled 7-(6-Fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole

18F-AV-1451

Flortaucipir F-18

[(18)F]T807

F 18 T807

[18F]T807

[F18]T807
Definitions

A radioconjugate composed of the paired helical filament (PHF) tau binding agent flortaucipir, a benzimidazole pyrimidine derivative, conjugated to the radioisotope fluorine F 18, with potential tau positron emission tomography (PET) imaging activity. Upon administration, flortaucipir F-18 targets and binds to PHF-tau in the brain, which allows PET imaging of PHF-tau and analysis of phosphorylated PHF-tau aggregates (neurofibrillary tangles). Increased levels of PHF-tau and neurofibrillary tangles are correlated with the cognitive decline seen in neurodegenerative diseases, such as dementia, Alzheimer's disease (AD) and chemotherapy-induced cognitive impairment (CICI).
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C171887
CAS_Registry

1522051-90-6
code

C171887
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

CTRP

FDA
DEFINITION

A radioconjugate composed of the paired helical filament (PHF) tau binding agent flortaucipir, a benzimidazole pyrimidine derivative, conjugated to the radioisotope fluorine F 18, with potential tau positron emission tomography (PET) imaging activity. Upon administration, flortaucipir F-18 targets and binds to PHF-tau in the brain, which allows PET imaging of PHF-tau and analysis of phosphorylated PHF-tau aggregates (neurofibrillary tangles). Increased levels of PHF-tau and neurofibrillary tangles are correlated with the cognitive decline seen in neurodegenerative diseases, such as dementia, Alzheimer's disease (AD) and chemotherapy-induced cognitive impairment (CICI).
Display_Name

Flortaucipir F-18
FDA_UNII_Code

T1JP1KYU9O
FULL_SYN

Fluorine F18 T807

FLORTAUCIPIR F-18

Fluorine-18 Labeled 7-(6-Fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole

18F-AV-1451

Flortaucipir F-18

[(18)F]T807

F 18 T807

[18F]T807

[F18]T807
Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C75652
label

Flortaucipir F-18
NCI_Drug_Dictionary_ID

809198
NCI_META_CUI

CL1406084
Preferred_Name

Flortaucipir F-18
prefixIRI

Thesaurus:C171887
Semantic_Type

Pharmacologic Substance

Indicator, Reagent, or Diagnostic Aid
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2124
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