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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Progesterone Receptor | |
| Synonyms |
progesterone receptor Progesterone Receptor Nuclear Receptor Subfamily 3 Group C Member 3 Progesterone Receptor Isoform B Progesterone Receptor B NR3C3 PGR PR PRB PgR Pr |
|
| Definitions |
Progesterone receptor (933 aa, ~99 kDa) is encoded by the human PGR gene. This protein is involved in the regulation of transcription. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17075 |
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| ALT_DEFINITION |
A protein found inside the cells of the female reproductive tissue, some other types of tissue, and some cancer cells. The hormone progesterone will bind to the receptors inside the cells and may cause the cells to grow.
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| code |
C17075
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 |
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| Contributing_Source |
CTRP
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|
| DEFINITION |
Progesterone receptor (933 aa, ~99 kDa) is encoded by the human PGR gene. This protein is involved in the regulation of transcription.
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| DesignNote |
There are two progesterone receptors isoforms, A and B. The UniProt references have isoform B as the canonical form. Isoform B is associated with the activation of SRC/MAPK signaling, which isoform A is unable to do. (UniProt)
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| Display_Name |
Progesterone Receptor
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| FULL_SYN |
progesterone receptor Progesterone Receptor Nuclear Receptor Subfamily 3 Group C Member 3 Progesterone Receptor Isoform B Progesterone Receptor B NR3C3 PGR PR PRB PgR Pr
|
|
| label |
Progesterone Receptor
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|
| Legacy Concept Name |
Progesterone_Receptor
|
|
| NCI_META_CUI |
CL1798377
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|
| OMIM_Number |
607311
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|
| Preferred_Name |
Progesterone Receptor
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| prefixIRI |
Thesaurus:C17075
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|
| Semantic_Type |
Amino Acid, Peptide, or Protein Receptor
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| Swiss_Prot |
P06401
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| subClassOf |
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