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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Glucocorticoid Receptor | |
| Synonyms |
Nuclear Receptor Subfamily 3 Group C Member 1 Glucocorticoid Receptor, Lymphocyte Nuclear Receptor Subfamily 3, Group C, Member 1 Glucocorticoid Receptor GR NR3C1 |
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| Definitions |
Glucocorticoid receptor (777 aa, ~86 kDa) is encoded by the human NR3C1 gene. This protein plays a role in both chromatin remodeling and transcriptional regulation. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17071 |
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| code |
C17071
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 |
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| Contributing_Source |
CTRP
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| DEFINITION |
Glucocorticoid receptor (777 aa, ~86 kDa) is encoded by the human NR3C1 gene. This protein plays a role in both chromatin remodeling and transcriptional regulation.
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| DesignNote |
Complexed with HSP90, HSP70, and FKBP5 or PPP5C, activated GR is transported (by dynein/FKBP4) to the nucleus and binds to target GREs as a homodimeric or heterodimeric (NR3C2/RXR) transcription factor and modulates other transcription factors to regulate blood glucose concentration, protein/fat metabolism, inflammatory responses, cell proliferation, and differentiation. GR appears to interact with NRIP1, POU2F1, POU2F2, STAT5A, STAT5B, SMARCA4, CREBBP/EP300, TADA2L, p160, NCOA2, and NCOA6. Sumoylation and BAG1 interaction inhibits transactivation.
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| Display_Name |
Glucocorticoid Receptor
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| FULL_SYN |
Nuclear Receptor Subfamily 3 Group C Member 1 Glucocorticoid Receptor, Lymphocyte Nuclear Receptor Subfamily 3, Group C, Member 1 Glucocorticoid Receptor GR NR3C1
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|
| label |
Glucocorticoid Receptor
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| Legacy Concept Name |
Glucocorticoid_Receptor
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| OMIM_Number |
138040
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| Preferred_Name |
Glucocorticoid Receptor
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| prefixIRI |
Thesaurus:C17071
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| Semantic_Type |
Amino Acid, Peptide, or Protein Receptor
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| Swiss_Prot |
P04150
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| UMLS_CUI |
C0034809
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| subClassOf |
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