loading...| Preferred Name |
Androgen Receptor |
|
| Synonyms |
Nuclear Receptor Subfamily 3 Group C Member 4 Dihydrotestosterone Receptor Androgen Receptor AR DHTR NR3C4 |
|
| Definitions |
Androgen receptor (919 aa, ~99 kDa) is encoded by the human AR gene. This protein plays a role in the modulation of steroid-dependent gene transcription. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17063 |
|
| code |
C17063 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142800 |
|
| Contributing_Source |
CTRP |
|
| DEFINITION |
Androgen receptor (919 aa, ~99 kDa) is encoded by the human AR gene. This protein plays a role in the modulation of steroid-dependent gene transcription. |
|
| DesignNote |
AR has 3 domains: N-terminal modulating (exon 1), DNA-binding (two C4 Zinc fingers, exons 2-3), and C-terminal hormone-binding (5 remaining exons). Polymorphic N-terminal poly-Gln tracts bind RAN, enhancing transactivation; decreased with increased poly-Gln length. An 87-kD (AR-A) isoform lacks a normal N-terminus, seen in the 110 kD (AR-B) form; A and B may differ in function. Ligand bound receptor translocates to the nucleus, homodimerizes, binds DNA, and stimulates transcription. |
|
| Display_Name |
Androgen Receptor |
|
| FULL_SYN |
Nuclear Receptor Subfamily 3 Group C Member 4 Dihydrotestosterone Receptor Androgen Receptor AR DHTR NR3C4 |
|
| label |
Androgen Receptor |
|
| Legacy Concept Name |
Androgen_Receptor |
|
| OMIM_Number |
313700 |
|
| Preferred_Name |
Androgen Receptor |
|
| prefixIRI |
Thesaurus:C17063 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Receptor |
|
| Swiss_Prot |
P10275 |
|
| UMLS_CUI |
C0034786 |
|
| subClassOf |