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National Cancer Institute Thesaurus
| Preferred Name | Levofloxacin Anhydrous | |
| Synonyms |
LEVOFLOXACIN ANHYDROUS (S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic Acid 7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic Acid, 9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (S)- Levofloxacin Anhydrous |
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| Definitions |
The anhydrous form of levofloxacin, a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C170539 |
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| CAS_Registry |
100986-85-4
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| Chemical_Formula |
C18H20FN3O4
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|
| code |
C170539
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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| DEFINITION |
The anhydrous form of levofloxacin, a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth.
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| FDA_UNII_Code |
RIX4E89Y14
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| FULL_SYN |
LEVOFLOXACIN ANHYDROUS (S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic Acid 7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic Acid, 9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (S)- Levofloxacin Anhydrous
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|
| label |
Levofloxacin Anhydrous
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| NCI_META_CUI |
CL1382974
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| Preferred_Name |
Levofloxacin Anhydrous
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| prefixIRI |
Thesaurus:C170539
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| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
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| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
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| Mapping To | Ontology | Source |
|---|---|---|
| http://purl.obolibrary.org/obo/NCIT_C170539 | BERO | LOOM |
| http://purl.bioontology.org/ontology/SNOMEDCT/785695006 | SNOMEDCT | LOOM |
| http://purl.bioontology.org/ontology/RXNORM/1546009 | RXNORM | LOOM |