National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Ipratropium Bromide Anhydrous
Synonyms

Ipratropium Bromide Anhydrous

1-alpha-H,5-alpha-H-Tropanium, 3-Alpha-hydroxy-8-isopropyl-, Bromide, (+-)-Tropate

IPRATROPIUM BROMIDE ANHYDROUS

8-Isopropylnoratropine Methobromide
Definitions

The bromide salt form of anhydrous ipratropium, a synthetic derivative of the alkaloid atropine with anticholinergic properties. Ipratropium antagonizes the actions of acetylcholine at parasympathetic, postganglionic, effector-cell junctions. When inhaled, ipratropium binds competitively to cholinergic receptors in the bronchial smooth muscle thereby blocking the bronchoconstrictor actions of the acetylcholine mediated vagal impulses. Inhibition of the vagal tone leads to dilation of the large central airways resulting in bronchodilation.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C170538
CAS_Registry

22254-24-6
Chemical_Formula

C20H30NO3.Br
code

C170538
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

FDA
DEFINITION

The bromide salt form of anhydrous ipratropium, a synthetic derivative of the alkaloid atropine with anticholinergic properties. Ipratropium antagonizes the actions of acetylcholine at parasympathetic, postganglionic, effector-cell junctions. When inhaled, ipratropium binds competitively to cholinergic receptors in the bronchial smooth muscle thereby blocking the bronchoconstrictor actions of the acetylcholine mediated vagal impulses. Inhibition of the vagal tone leads to dilation of the large central airways resulting in bronchodilation.
FDA_UNII_Code

VJV4X1P2Z1
FULL_SYN

Ipratropium Bromide Anhydrous

1-alpha-H,5-alpha-H-Tropanium, 3-Alpha-hydroxy-8-isopropyl-, Bromide, (+-)-Tropate

IPRATROPIUM BROMIDE ANHYDROUS

8-Isopropylnoratropine Methobromide
Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61794
label

Ipratropium Bromide Anhydrous
Legacy Concept Name

Ipratropium_Bromide
NCI_META_CUI

CL1382973
Preferred_Name

Ipratropium Bromide Anhydrous
prefixIRI

Thesaurus:C170538
Semantic_Type

Pharmacologic Substance
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29704

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C319
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