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National Cancer Institute Thesaurus
| Preferred Name | Ibandronate Sodium | |
| Synonyms |
Ibandronate Sodium IBANDRONATE SODIUM ibandronate Bondronate Boniva |
|
| Definitions |
The sodium salt form of ibandronic acid, a synthetic nitrogen-containing bisphosphonate. Ibandronic acid inhibits farnesyl pyrophosphate synthase, resulting in a reduction in geranylgeranyl GTPase signaling proteins and apoptosis of osteoclasts. This agent increases bone mineral density, decreases bone remodeling, inhibits osteoclast-mediated bone resorption, and reduces metastases-related and corticosteroid-related bone pain. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1670 |
|
| Accepted_Therapeutic_Use_For |
Osteoporosis, treatment and prevention
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|
| ALT_DEFINITION |
A drug that is used to prevent and treat osteoporosis, and is being studied in the treatment of cancer that has spread to the bones. It belongs to the family of drugs called bisphosphonates.
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|
| CAS_Registry |
138926-19-9
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|
| Chemical_Formula |
C9H22NO7P2.Na.H2O
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|
| code |
C1670
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
CTRP FDA GDC
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|
| DEFINITION |
The sodium salt form of ibandronic acid, a synthetic nitrogen-containing bisphosphonate. Ibandronic acid inhibits farnesyl pyrophosphate synthase, resulting in a reduction in geranylgeranyl GTPase signaling proteins and apoptosis of osteoclasts. This agent increases bone mineral density, decreases bone remodeling, inhibits osteoclast-mediated bone resorption, and reduces metastases-related and corticosteroid-related bone pain.
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|
| Display_Name |
Ibandronate Sodium
|
|
| FDA_UNII_Code |
J12U072QL0
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|
| FULL_SYN |
Ibandronate Sodium IBANDRONATE SODIUM ibandronate Bondronate Boniva
|
|
| Is_Value_For_GDC_Property | ||
| label |
Ibandronate Sodium
|
|
| Legacy Concept Name |
Ibandronate
|
|
| Maps_To |
Ibandronate Sodium
|
|
| NCI_Drug_Dictionary_ID |
365963
|
|
| PDQ_Closed_Trial_Search_ID |
365963
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|
| PDQ_Open_Trial_Search_ID |
365963
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|
| Preferred_Name |
Ibandronate Sodium
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|
| prefixIRI |
Thesaurus:C1670
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0772244
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|
| subClassOf |
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