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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Becaplermin | |
| Synonyms |
Platelet-Derived Growth Factor Beta Chain PDGF Beta Chain BECAPLERMIN Platlet-Derived Growth Factor Beta Chain Recombinant Platelet Derived Growth Factor Beta Chain Becaplermin Regranex rhPDGF-BB |
|
| Definitions |
The recombinant analog of endogenous beta (B) chain of the cytokine platelet-derived growth factor (PDGF). Synthesized primarily by megakaryocytes, endogenous PDGF consists of two related peptide chains, PDGF-A and PDGF-B. PDGF functions as a local autocrine and paracrine growth factor in many cellular processes. Recombinant PDGF, alone and in combination with other agents, may be useful in promoting bone formation and soft tissue repair. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1668 |
|
| CAS_Registry |
165101-51-9
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|
| code |
C1668
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
The recombinant analog of endogenous beta (B) chain of the cytokine platelet-derived growth factor (PDGF). Synthesized primarily by megakaryocytes, endogenous PDGF consists of two related peptide chains, PDGF-A and PDGF-B. PDGF functions as a local autocrine and paracrine growth factor in many cellular processes. Recombinant PDGF, alone and in combination with other agents, may be useful in promoting bone formation and soft tissue repair. (NCI04)
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|
| FDA_UNII_Code |
1B56C968OA
|
|
| FULL_SYN |
Platelet-Derived Growth Factor Beta Chain PDGF Beta Chain BECAPLERMIN Platlet-Derived Growth Factor Beta Chain Recombinant Platelet Derived Growth Factor Beta Chain Becaplermin Regranex rhPDGF-BB
|
|
| label |
Becaplermin
|
|
| Legacy Concept Name |
Therapeutic_Platelet_Derived_Growth_Factor_Beta_Chain
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|
| Preferred_Name |
Becaplermin
|
|
| prefixIRI |
Thesaurus:C1668
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|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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|
| UMLS_CUI |
C0379135
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|
| subClassOf |
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