National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Daclatasvir Dihydrochloride
Synonyms

Daclatasvir Dihydrochloride

DACLATASVIR DIHYDROCHLORIDE
Definitions

The dihydrochloride salt form of daclatasvir, an orally available inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A) replication complex, with potential activity against HCV. Although the exact mechanism of action of daclatasvir has yet to be fully determined, this agent, upon oral administration and after intracellular uptake, appears to bind to domain I of the NS5A protein. This inhibits the activity of the NS5A protein and results in the disruption of the viral RNA replication complex, blockage of viral HCV RNA production, and inhibition of viral replication. NS5A, a zinc-binding and proline-rich hydrophilic phosphoprotein, plays a crucial role in HCV RNA replication. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C166798
CAS_Registry

1009119-65-6
code

C166798
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

FDA
DEFINITION

The dihydrochloride salt form of daclatasvir, an orally available inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A) replication complex, with potential activity against HCV. Although the exact mechanism of action of daclatasvir has yet to be fully determined, this agent, upon oral administration and after intracellular uptake, appears to bind to domain I of the NS5A protein. This inhibits the activity of the NS5A protein and results in the disruption of the viral RNA replication complex, blockage of viral HCV RNA production, and inhibition of viral replication. NS5A, a zinc-binding and proline-rich hydrophilic phosphoprotein, plays a crucial role in HCV RNA replication. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family.
FDA_UNII_Code

50ZO25C11D
FULL_SYN

Daclatasvir Dihydrochloride

DACLATASVIR DIHYDROCHLORIDE
label

Daclatasvir Dihydrochloride
NCI_META_CUI

CL971792
Preferred_Name

Daclatasvir Dihydrochloride
prefixIRI

Thesaurus:C166798
Semantic_Type

Pharmacologic Substance

Nucleic Acid, Nucleoside, or Nucleotide
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C281
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