loading...| Preferred Name | Cathepsin | |
| Synonyms |
CATHEPSIN Cathepsin Cathepsins |
|
| Definitions |
Lysosomal proteinases or endopeptidases that function optimally at an acidic pH to catalyze the hydrolysis of peptidic bonds. Elevated cathepsin enzyme activity in either serum or extracellular matrix is often indicative of pathological conditions such as Alzheimer's disease, several types of cancer, arthritis, and osteoporosis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16389 |
|
| ALT_DEFINITION |
Antigen(s) of the lysosomal proteinase or endopeptidase family and are encoded by the CTS gene. They can be considered as autoantigens and are commonly associated with systemic vasculitis, inflammatory rheumatic diseases, autoimmune hepatitis, and chronic inflammatory bowel diseases. |
|
| code |
C16389 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66830 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61410 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142800 |
|
| Contributing_Source |
CDISC CTRP |
|
| DEFINITION |
Lysosomal proteinases or endopeptidases that function optimally at an acidic pH to catalyze the hydrolysis of peptidic bonds. Elevated cathepsin enzyme activity in either serum or extracellular matrix is often indicative of pathological conditions such as Alzheimer's disease, several types of cancer, arthritis, and osteoporosis. |
|
| Display_Name |
Cathepsin |
|
| FULL_SYN |
CATHEPSIN Cathepsin Cathepsins |
|
| label |
Cathepsin |
|
| Legacy Concept Name |
Cathepsin |
|
| Preferred_Name |
Cathepsin |
|
| prefixIRI |
Thesaurus:C16389 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Enzyme |
|
| UMLS_CUI |
C0007428 |
|
| subClassOf |