National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Cathepsin

Synonyms

CATHEPSIN

Cathepsin

Cathepsins

Definitions

Lysosomal proteinases or endopeptidases that function optimally at an acidic pH to catalyze the hydrolysis of peptidic bonds. Elevated cathepsin enzyme activity in either serum or extracellular matrix is often indicative of pathological conditions such as Alzheimer's disease, several types of cancer, arthritis, and osteoporosis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16389

ALT_DEFINITION

Antigen(s) of the lysosomal proteinase or endopeptidase family and are encoded by the CTS gene. They can be considered as autoantigens and are commonly associated with systemic vasculitis, inflammatory rheumatic diseases, autoimmune hepatitis, and chronic inflammatory bowel diseases.

code

C16389

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66830

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61410

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142800

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C181169

Contributing_Source

CDISC

CTRP

DEFINITION

Lysosomal proteinases or endopeptidases that function optimally at an acidic pH to catalyze the hydrolysis of peptidic bonds. Elevated cathepsin enzyme activity in either serum or extracellular matrix is often indicative of pathological conditions such as Alzheimer's disease, several types of cancer, arthritis, and osteoporosis.

Display_Name

Cathepsin

FULL_SYN

CATHEPSIN

Cathepsin

Cathepsins

label

Cathepsin

Legacy Concept Name

Cathepsin

Preferred_Name

Cathepsin

prefixIRI

Thesaurus:C16389

Semantic_Type

Amino Acid, Peptide, or Protein

Enzyme

UMLS_CUI

C0007428

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16965

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