loading...| Preferred Name | Alpha-Fetoprotein | |
| Synonyms |
Alpha-Fetoprotein alpha-Fetoprotein Alpha Fetal Protein Alpha Fetoprotein Alpha-1-Fetoprotein Alpha-Fetoglobulin alpha-fetoprotein AFP |
|
| Definitions |
Alpha-fetoprotein (609 aa, ~69 kDa) is encoded by the human AFP gene. This protein plays a role in the binding to copper, nickel, bilirubin and fatty acids in the fetal circulation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16278 |
|
| ALT_DEFINITION |
A protein normally produced by a fetus. AFP levels are usually undetectable in the blood of healthy adult men or women (who are not pregnant). An elevated level of AFP suggests the presence of either a primary liver cancer or germ cell tumor. |
|
| code |
C16278 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 |
|
| Contributing_Source |
CTRP |
|
| DEFINITION |
Alpha-fetoprotein (609 aa, ~69 kDa) is encoded by the human AFP gene. This protein plays a role in the binding to copper, nickel, bilirubin and fatty acids in the fetal circulation. |
|
| DesignNote |
Alpha-fetoprotein is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistence of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. (from LocusLink) |
|
| Display_Name |
Alpha-Fetoprotein |
|
| FULL_SYN |
Alpha-Fetoprotein alpha-Fetoprotein Alpha Fetal Protein Alpha Fetoprotein Alpha-1-Fetoprotein Alpha-Fetoglobulin alpha-fetoprotein AFP |
|
| label |
Alpha-Fetoprotein |
|
| Legacy Concept Name |
Alpha-Fetoprotein |
|
| OMIM_Number |
104150 |
|
| Preferred_Name |
Alpha-Fetoprotein |
|
| prefixIRI |
Thesaurus:C16278 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein |
|
| Swiss_Prot |
P02771 |
|
| UMLS_CUI |
C1307640 |
|
| subClassOf |