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National Cancer Institute Thesaurus
| Preferred Name | Cidofovir | |
| Synonyms |
Cidofovir Dihydrate 1(3-hydroxy-2-phosphonomethoxypropyl) Cytosine CDV CIDOFOVIR Cidofovir DRG-0145 GS-0504 HPMPC Vistide cidofovir |
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| Definitions |
A synthetic, acyclic, monophosphate nucleotide analog of deoxycytidine with antiviral activity, and mostly used against cytomegalovirus (CMV). After incorporation into the host cell, cidofovir is phosphorylated by pyruvate kinases to its active metabolite cidofovir diphosphate. Cidofovir diphosphate, bearing structural similarity to nucleotides, competes with deoxycytosine-5-triphosphate (dCTP) for viral DNA polymerase and gets incorporated into the growing viral DNA strands. As a result, it prevents further DNA polymerization and disrupts DNA replication of viruses. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1600 |
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| ALT_DEFINITION |
A drug used to treat infection caused by viruses.
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| CAS_Registry |
149394-66-1
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|
| CHEBI_ID |
CHEBI:59495
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|
| Chemical_Formula |
C8H14N3O6P.2H2O
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|
| code |
C1600
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA
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|
| DEFINITION |
A synthetic, acyclic, monophosphate nucleotide analog of deoxycytidine with antiviral activity, and mostly used against cytomegalovirus (CMV). After incorporation into the host cell, cidofovir is phosphorylated by pyruvate kinases to its active metabolite cidofovir diphosphate. Cidofovir diphosphate, bearing structural similarity to nucleotides, competes with deoxycytosine-5-triphosphate (dCTP) for viral DNA polymerase and gets incorporated into the growing viral DNA strands. As a result, it prevents further DNA polymerization and disrupts DNA replication of viruses.
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|
| Display_Name |
Cidofovir
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|
| FDA_UNII_Code |
JIL713Q00N
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|
| FULL_SYN |
Cidofovir Dihydrate 1(3-hydroxy-2-phosphonomethoxypropyl) Cytosine CDV CIDOFOVIR Cidofovir DRG-0145 GS-0504 HPMPC Vistide cidofovir
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|
| Has_Target | ||
| label |
Cidofovir
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|
| Legacy Concept Name |
Cidofovir
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| NCI_Drug_Dictionary_ID |
42545
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| PDQ_Closed_Trial_Search_ID |
42545
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|
| PDQ_Open_Trial_Search_ID |
42545
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|
| Preferred_Name |
Cidofovir
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|
| prefixIRI |
Thesaurus:C1600
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|
| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
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| UMLS_CUI |
C0286079
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| subClassOf |
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