loading...| Preferred Name | Antineoplastic Alkylating Agent | |
| Synonyms |
Antineoplastic Alkylating Agent Chemotherapy Alkylating Agents Chemotherapy Alkylators |
|
| Definitions |
An antineoplastic agent that replaces hydrogen atom(s) in nucleophilic moieties with alky radical(s), hindering proper function. Alkylating agents exhibit cytotoxic effects through the alkylation of DNA, resulting in strand cross-linking, ultimately inhibiting DNA replication and cancer cell growth. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1590 |
|
| code |
C1590 |
|
| DEFINITION |
An antineoplastic agent that replaces hydrogen atom(s) in nucleophilic moieties with alky radical(s), hindering proper function. Alkylating agents exhibit cytotoxic effects through the alkylation of DNA, resulting in strand cross-linking, ultimately inhibiting DNA replication and cancer cell growth. |
|
| FULL_SYN |
Antineoplastic Alkylating Agent Chemotherapy Alkylating Agents Chemotherapy Alkylators |
|
| label |
Antineoplastic Alkylating Agent |
|
| Legacy Concept Name |
Antineoplastic_Alkylating_Agent |
|
| Preferred_Name |
Antineoplastic Alkylating Agent |
|
| prefixIRI |
Thesaurus:C1590 |
|
| Semantic_Type |
Chemical Viewed Functionally |
|
| UMLS_CUI |
C0282532 |
|
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/NCIT_C1590 | BERO | LOOM |