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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1583
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1583
|
|---|---|
| Preferred Name | Daunorubicin Hydrochloride |
| Definitions |
The hydrochloride salt of an anthracycline antineoplastic antibiotic with therapeutic effects similar to those of doxorubicin. Daunorubicin exhibits cytotoxic activity through topoisomerase-mediated interaction with DNA, thereby inhibiting DNA replication and repair and RNA and protein synthesis.
|
| Synonyms |
Daunorubicin Hydrochloride
Daunoblastine
Daunoblastin
Daunoblastina
Daunomycin Hydrochloride
DAUNORUBICIN HYDROCHLORIDE
Daunorubicini Hydrochloridum
L-lyxo-Hexopyranoside, 3beta-acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-metldioxo-1a-naphthacenyl 3-amino-2,3,6-trideoxy-,alpha-,hydrochloride
Rubidomycin Hydrochloride
daunorubicin hydrochloride
Cloridrato de Daunorubicina
Daunorubicin.HCl
Daunomycin hydrochloride
5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride, (8S-cis)-(9CI)
Daunomycin, hydrochloride
5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-, hydrochloride
Daunorubicin hydrochloride
daunomycin hydrochloride
CERUBIDINE
Cerubidin
Cerubidine
FI-6339
Ondena
RP-13057
Rubilem
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|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Daunorubicin Hydrochloride
|
|---|---|
| Maps_To |
Daunorubicin Hydrochloride
|
| Accepted_Therapeutic_Use_For |
Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia
|
| Legacy Concept Name |
Daunomycin
|
| NCI_Drug_Dictionary_ID |
39779
|
| Is_Value_For_GDC_Property | |
| PDQ_Closed_Trial_Search_ID |
39779
|
| Preferred_Name |
Daunorubicin Hydrochloride
|
| Display_Name |
Daunorubicin Hydrochloride
|
| Semantic_Type |
Pharmacologic Substance
|
| prefixIRI |
Thesaurus:C1583
|
| DEFINITION |
The hydrochloride salt of an anthracycline antineoplastic antibiotic with therapeutic effects similar to those of doxorubicin. Daunorubicin exhibits cytotoxic activity through topoisomerase-mediated interaction with DNA, thereby inhibiting DNA replication and repair and RNA and protein synthesis.
|
| UMLS_CUI |
C0282123
|
| code |
C1583
|
| Chemical_Formula |
C27H29NO10.HCl
|
| subClassOf | |
| NSC Number |
82151
83142
|
| type | |
| CAS_Registry |
23541-50-6
|
| FULL_SYN |
Daunorubicin Hydrochloride
Daunoblastine
Daunoblastin
Daunoblastina
Daunomycin Hydrochloride
DAUNORUBICIN HYDROCHLORIDE
Daunorubicini Hydrochloridum
L-lyxo-Hexopyranoside, 3beta-acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-metldioxo-1a-naphthacenyl 3-amino-2,3,6-trideoxy-,alpha-,hydrochloride
Rubidomycin Hydrochloride
daunorubicin hydrochloride
Cloridrato de Daunorubicina
Daunorubicin.HCl
Daunomycin hydrochloride
5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride, (8S-cis)-(9CI)
Daunomycin, hydrochloride
5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-, hydrochloride
Daunorubicin hydrochloride
daunomycin hydrochloride
CERUBIDINE
Cerubidin
Cerubidine
FI-6339
Ondena
RP-13057
Rubilem
See more
See less
|
| FDA_UNII_Code |
UD984I04LZ
|
| ALT_DEFINITION |
A drug used to treat acute leukemias and some other types of cancer. It blocks a certain enzyme needed for cell division and DNA repair, and it may kill cancer cells. Cerubidine is a type of anthracycline antibiotic and a type of topoisomerase inhibitor.
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| PDQ_Open_Trial_Search_ID |
39779
|
| Contributing_Source |
CTRP
FDA
GDC
|
| Concept_In_Subset |
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|
| Has_Target | |
| Has_Free_Acid_Or_Base_Form |
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