loading...| Preferred Name |
Levoleucovorin |
|
| Synonyms |
LEVOLEUCOVORIN Elvorine, Isovorin, Levofolene, Levorin Levofolinate Levofolinic acid L-5-Formyltetrahydrofolate L-Leucovorin Levoleucovorin CL-307,782 Isovorin |
|
| Definitions |
The active l-isomer of the racemic mixture of the 5-formyl derivative of tetrahydrofolic acid. Metabolically active, l-leucovorin, also known levoleucovorin, does not require bioactivation by dihydrofolate reductase, an enzyme inhibited by folic acid antagonists. This agent may enhance the effects of fluoropyrimidines by stabilizing their binding to the enzyme thymidylate synthase. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1559 |
|
| CAS_Registry |
58-05-9 |
|
| CHEBI_ID |
CHEBI:63606 |
|
| Chemical_Formula |
C20H23N7O7 |
|
| code |
C1559 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
|
| Contributing_Source |
CTRP FDA HemOnc |
|
| DEFINITION |
The active l-isomer of the racemic mixture of the 5-formyl derivative of tetrahydrofolic acid. Metabolically active, l-leucovorin, also known levoleucovorin, does not require bioactivation by dihydrofolate reductase, an enzyme inhibited by folic acid antagonists. This agent may enhance the effects of fluoropyrimidines by stabilizing their binding to the enzyme thymidylate synthase. (NCI04) |
|
| Display_Name |
Levoleucovorin |
|
| FDA_UNII_Code |
990S25980Y |
|
| FULL_SYN |
LEVOLEUCOVORIN Elvorine, Isovorin, Levofolene, Levorin Levofolinate Levofolinic acid L-5-Formyltetrahydrofolate L-Leucovorin Levoleucovorin CL-307,782 Isovorin |
|
| Has_Salt_Form | ||
| label |
Levoleucovorin |
|
| Legacy Concept Name |
L-Leucovorin |
|
| NCI_Drug_Dictionary_ID |
40490 |
|
| PDQ_Closed_Trial_Search_ID |
40490 |
|
| PDQ_Open_Trial_Search_ID |
40490 |
|
| Preferred_Name |
Levoleucovorin |
|
| prefixIRI |
Thesaurus:C1559 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C2721771 |
|
| subClassOf |