National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

C-myb Antisense Oligonucleotide G4460
Synonyms

C-myb Antisense Oligonucleotide G4460

c-Myb Antisense OND

c-MYB Antisense Oligodeoxynucleotide

c-Myb LR-3001

c-MYB Antisense

G4460

INX-3001

LR-3001

OL(1)p53
Definitions

A 24-base phosphorothiolate antisense oligodeoxynucleotide (ODN) for the proto-oncogene c-myb with potential antineoplastic activity. C-myb antisense oligonucleotide G4460 binds to codon sequences 2 to 9 of c-myb mRNA, inhibiting translation of the transcript. Suppression of c-myb expression with this agent may result in the restoration of normal differentiation pathways, increased antiproliferative effects, and the induction of apoptosis in early progenitor hematopoietic cells and in tumor cells that overexpress c-myb. Tumor-cell overexpression of c-myb blocks differentiation, promotes proliferation, and inhibits apoptosis.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1541
code

C1541
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537
Contributing_Source

GDC
DEFINITION

A 24-base phosphorothiolate antisense oligodeoxynucleotide (ODN) for the proto-oncogene c-myb with potential antineoplastic activity. C-myb antisense oligonucleotide G4460 binds to codon sequences 2 to 9 of c-myb mRNA, inhibiting translation of the transcript. Suppression of c-myb expression with this agent may result in the restoration of normal differentiation pathways, increased antiproliferative effects, and the induction of apoptosis in early progenitor hematopoietic cells and in tumor cells that overexpress c-myb. Tumor-cell overexpression of c-myb blocks differentiation, promotes proliferation, and inhibits apoptosis.
FULL_SYN

C-myb Antisense Oligonucleotide G4460

c-Myb Antisense OND

c-MYB Antisense Oligodeoxynucleotide

c-Myb LR-3001

c-MYB Antisense

G4460

INX-3001

LR-3001

OL(1)p53
Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909
label

C-myb Antisense Oligonucleotide G4460
Legacy Concept Name

LR-3001
Maps_To

C-myb Antisense Oligonucleotide G4460
NCI_Drug_Dictionary_ID

43388
NSC Number

710296
PDQ_Closed_Trial_Search_ID

43388
PDQ_Open_Trial_Search_ID

43388
Preferred_Name

C-myb Antisense Oligonucleotide G4460
prefixIRI

Thesaurus:C1541
Semantic_Type

Pharmacologic Substance

Nucleic Acid, Nucleoside, or Nucleotide
UMLS_CUI

C0253788
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1291
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