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National Cancer Institute Thesaurus
| Preferred Name | Docetaxel | |
| Synonyms |
N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol [2aR-[2a alphaa,4beta,4a beta,6beta,9alpha,(alphaR*,betaS*),-11alpha,12alpha,12a alpha,12b alpha]]-beta-[[(1,1-dimethylethoxy)carbonyl]-amino]-alpha-hydroxybenzemepropanoic Acid 12b-(Acetyloxy)-12(benzyloxy)-2a,3,4,4a,5,6,8,10,11,12,12a,12b-dodecahydeo-4,-6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester Taxotere Injection Concentrate DOCETAXEL Docecad Docetaxel RP 56976 RP56976 Taxotere docetaxel |
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| Definitions |
A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. (NCI04) |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526 |
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| Accepted_Therapeutic_Use_For |
Breast cancer; Esophageal cancer; Gastric cancer; Head/Neck cancers; Locally Advanced or Metastatic Non small-cell lung cancer; Ovarian cancer; Metastatic Prostate cancer
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| ALT_DEFINITION |
A drug used together with other drugs to treat certain types of breast cancer, stomach cancer, prostate cancer, and certain types of head and neck cancer. It is also being studied in the treatment of other types of cancer. Docetaxel is a type of mitotic inhibitor.
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| CAS_Registry |
148408-66-6
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| CHEBI_ID |
CHEBI:59809
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| Chemical_Formula |
C43H53NO14.3H2O
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|
| code |
C1526
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179531 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192234 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 |
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| Contributing_Source |
CTRP FDA GDC HemOnc OORO PCDC
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|
| DEFINITION |
A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. (NCI04)
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|
| Display_Name |
Docetaxel
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| FDA_UNII_Code |
15H5577CQD
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| FULL_SYN |
N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol [2aR-[2a alphaa,4beta,4a beta,6beta,9alpha,(alphaR*,betaS*),-11alpha,12alpha,12a alpha,12b alpha]]-beta-[[(1,1-dimethylethoxy)carbonyl]-amino]-alpha-hydroxybenzemepropanoic Acid 12b-(Acetyloxy)-12(benzyloxy)-2a,3,4,4a,5,6,8,10,11,12,12a,12b-dodecahydeo-4,-6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester Taxotere Injection Concentrate DOCETAXEL Docecad Docetaxel RP 56976 RP56976 Taxotere docetaxel
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| Has_Target |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20450 |
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| Is_Value_For_GDC_Property | ||
| label |
Docetaxel
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| Legacy Concept Name |
Docetaxel
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| Maps_To |
Docetaxel
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| NCI_Drug_Dictionary_ID |
41657
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| NSC Number |
628503
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| PDQ_Closed_Trial_Search_ID |
41657
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| PDQ_Open_Trial_Search_ID |
41657
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| Preferred_Name |
Docetaxel
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| prefixIRI |
Thesaurus:C1526
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0246415
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| subClassOf |
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