loading...| Preferred Name |
Gene Therapy |
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| Synonyms |
DNA Therapy Gene Therapy Molecular Biology, Gene Therapy gene therapy Intervention, Genetic Gene transfer Gene Transfer Procedure GENETIC |
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| Definitions |
Application of genetic material (usually DNA) into cells in order to permanently correct an inherited disease or acquired disease. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C15238 |
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| ALT_DEFINITION |
Therapy based on ex vivo or in vivo gene modification of cells using specific technologies, e.g., viral vectors and direct genome editing technologies. NOTE: A particular example of this is the therapy with gene-modified T cells (chimeric antigen receptor (CAR) T-cell therapies) used as immunotherapy in oncology. [After Natalie Mount, et al. Cell-based therapy technology classifications and translational challenge. Philos Trans R Soc Lond B Biol Sci. 2015 Oct 19; 370(1680): 20150017.] See also cell therapy, regenerative medicine therapy, regenerative medicine advanced therapy, biological product. Treatment that alters a gene. In studies of gene therapy for cancer, researchers are trying to improve the body's natural ability to fight the disease or to make the cancer cells more sensitive to other kinds of therapy. Treatment of human disease by gene transfer. Introduction of genetic material into cells in order to correct or treat an inherited or acquired disease. |
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| code |
C15238 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66830 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132298 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61410 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118169 |
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| Contributing_Source |
CDISC-GLOSS CDISC CTRP |
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| DEFINITION |
Application of genetic material (usually DNA) into cells in order to permanently correct an inherited disease or acquired disease. |
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| DesignNote |
Gene therapy techniques attempt to replace a faulty or missing gene associated with a particular disease, mediate localized delivery of a protein producing specified therapeutic effects, or introduce new cellular functions. |
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| Display_Name |
Gene Therapy |
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| FULL_SYN |
DNA Therapy Gene Therapy Molecular Biology, Gene Therapy gene therapy Intervention, Genetic Gene transfer Gene Transfer Procedure GENETIC |
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| label |
Gene Therapy |
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| Legacy Concept Name |
Gene_Therapy |
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| Preferred_Name |
Gene Therapy |
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| prefixIRI |
Thesaurus:C15238 |
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| Semantic_Type |
Therapeutic or Preventive Procedure |
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| UMLS_CUI |
C0017296 |
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| subClassOf |