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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1471
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1471
|
|---|---|
| Preferred Name | Lamivudine |
| Definitions |
A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. (NCI04)
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| Synonyms |
2',3'-Dideoxy-3'-thiacytidine
4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone
(-)-BCH-189
3'-Thia-2',3'-dideoxycytidine
3TC
Epivir
GR109714X
LAM
LAMIVUDINE
Lamivudine
lamivudine
See more
See less
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Lamivudine
|
|---|---|
| Accepted_Therapeutic_Use_For |
Chronic hepatitis B; HIV infection
|
| Legacy Concept Name |
Lamivudine
|
| CHEBI_ID |
CHEBI:63577
|
| NCI_Drug_Dictionary_ID |
42593
|
| PDQ_Closed_Trial_Search_ID |
42593
|
| Preferred_Name |
Lamivudine
|
| Display_Name |
Lamivudine
|
| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
|
| prefixIRI |
Thesaurus:C1471
|
| DEFINITION |
A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. (NCI04)
|
| UMLS_CUI |
C0209738
|
| code |
C1471
|
| Chemical_Formula |
C8H11N3O3S
|
| subClassOf | |
| type | |
| CAS_Registry |
134678-17-4
|
| FULL_SYN |
2',3'-Dideoxy-3'-thiacytidine
4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone
(-)-BCH-189
3'-Thia-2',3'-dideoxycytidine
3TC
Epivir
GR109714X
LAM
LAMIVUDINE
Lamivudine
lamivudine
See more
See less
|
| FDA_UNII_Code |
2T8Q726O95
|
| ALT_DEFINITION |
A drug used to treat infection caused by viruses.
|
| PDQ_Open_Trial_Search_ID |
42593
|
| Contributing_Source |
CTRP
FDA
HemOnc
|
| Concept_In_Subset |
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