loading...| Preferred Name |
Apolipoprotein(a) |
|
| Synonyms |
Apolipoprotein(a) Antiangiogenic AK38 Protein EC 3.4.21.- Apo(a) LPA Lp(a) |
|
| Definitions |
Apolipoprotein(a) (4548 aa, ~501 kDa) is encoded by the human LPA gene. This protein is involved in the regulation of thrombosis and lipid metabolism. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C140118 |
|
| code |
C140118 |
|
| DEFINITION |
Apolipoprotein(a) (4548 aa, ~501 kDa) is encoded by the human LPA gene. This protein is involved in the regulation of thrombosis and lipid metabolism. |
|
| DesignNote |
Lipoprotein(a) (Lp(a)) is formed by the disulfide linkage of apolipoprotein B100 (APOB) of a low-density lipoprotein particle to apolipoprotein(a). (OMIM) Apolipoprotein(a) (apo(a)) is proteolytically cleaved, to form mini-Lp(a). These apo(a) fragments may accumulate in atherosclerotic lesions and promote thrombogenesis. O-glycosylation of apo(a) may limit proteolytic fragmentation. The shared homology of mini-Lp(a) with plasminogen kringles IV and V is thought to underlie the atherogenicity of the protein, as the fragments may compete with plasminogen for fibrin(ogen) binding. (UniProt) |
|
| FULL_SYN |
Apolipoprotein(a) Antiangiogenic AK38 Protein EC 3.4.21.- Apo(a) LPA Lp(a) |
|
| label |
Apolipoprotein(a) |
|
| NCI_META_CUI |
CL538292 |
|
| OMIM_Number |
152200 |
|
| Preferred_Name |
Apolipoprotein(a) |
|
| prefixIRI |
Thesaurus:C140118 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Enzyme |
|
| Swiss_Prot |
P08519 |
|
| subClassOf |