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National Cancer Institute Thesaurus
| Preferred Name | Leuprolide Acetate | |
| Synonyms |
Uno-Enantone Lupron Depot-3 Month Lucrin Depot 6-D-Leucine-9-(N-ethyl-L-prolinamide)-1-9-luteinizing Hormone-releasing Factor (Pig) Monoacetate Leuprorelin Acetate Lupron Depot-4 Month Abbott 43818 Lupron Depot-Ped leuprolide acetate 6-D-Leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide Luteinizing Hormone-Releasing Factor (Pig) Monoacetate LEUPROLIDE ACETATE Abbott-43818 Luprodex Depot Depo-Eligard Lupron Depot Enantone-Gyn Leuprolide Acetate A-43818 Carcinil Eligard Enanton Enantone Ginecrin LEUP Leuplin Lucrin Lupron Lutrate Procren Procrin Prostap TAP-144 Trenantone Viadur |
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| Definitions |
The acetate salt of a synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1319 |
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| Accepted_Therapeutic_Use_For |
Endometriosis; In-vitro fertilization; Precocious puberty; Premenstrual syndrome; Prostate cancer; Uterine fibroid tumors
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| ALT_DEFINITION |
A drug used to treat symptoms of advanced prostate cancer. It is also being studied in the treatment of other conditions and types of cancer. The active ingredient leuprolide blocks the body from making testosterone (a male hormone) and estradiol (a female hormone). It may stop the growth of prostate cancer cells that need testosterone to grow. Some brands of leuprolide are also used to treat early puberty in children and certain gynecologic conditions. Leuprolide acetate is a type of gonadotropin-releasing hormone analog.
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| CAS_Registry |
74381-53-6
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| CHEBI_ID |
CHEBI:63597
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| Chemical_Formula |
C59H84N16O12.C2H4O2
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|
| code |
C1319
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
CTRP FDA GDC
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| DEFINITION |
The acetate salt of a synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression.
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|
| Display_Name |
Leuprolide Acetate
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|
| FDA_UNII_Code |
37JNS02E7V
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|
| FULL_SYN |
Uno-Enantone Lupron Depot-3 Month Lucrin Depot 6-D-Leucine-9-(N-ethyl-L-prolinamide)-1-9-luteinizing Hormone-releasing Factor (Pig) Monoacetate Leuprorelin Acetate Lupron Depot-4 Month Abbott 43818 Lupron Depot-Ped leuprolide acetate 6-D-Leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide Luteinizing Hormone-Releasing Factor (Pig) Monoacetate LEUPROLIDE ACETATE Abbott-43818 Luprodex Depot Depo-Eligard Lupron Depot Enantone-Gyn Leuprolide Acetate A-43818 Carcinil Eligard Enanton Enantone Ginecrin LEUP Leuplin Lucrin Lupron Lutrate Procren Procrin Prostap TAP-144 Trenantone Viadur
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| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Leuprolide Acetate
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| Legacy Concept Name |
Leuprolide
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|
| Maps_To |
Leuprolide Acetate
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| NCI_Drug_Dictionary_ID |
40058
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| PDQ_Closed_Trial_Search_ID |
40058
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| PDQ_Open_Trial_Search_ID |
40058
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| Preferred_Name |
Leuprolide Acetate
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| prefixIRI |
Thesaurus:C1319
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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| UMLS_CUI |
C0700596
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| subClassOf |
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