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National Cancer Institute Thesaurus
| Preferred Name | Tacrolimus | |
| Synonyms |
Hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone FK 506 FK-506 Fujimycin Hecoria Prograf Protopic TACROLIMUS Tacforius Tacrolimus tacrolimus |
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| Definitions |
A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311 |
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| Accepted_Therapeutic_Use_For |
Atopic dermatitis; Kidney transplant rejection, prophylaxis; Liver transplant rejection, prophylaxis
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| ALT_DEFINITION |
A drug used to help reduce the risk of rejection by the body of organ and bone marrow transplants.
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| CAS_Registry |
109581-93-3
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| CHEBI_ID |
CHEBI:61057
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| Chemical_Formula |
C44H69NO12.H2O
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|
| code |
C1311
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
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| Contributing_Source |
CTRP FDA HemOnc
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|
| DEFINITION |
A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.
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|
| Display_Name |
Tacrolimus
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| FDA_UNII_Code |
WM0HAQ4WNM
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| FULL_SYN |
Hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone FK 506 FK-506 Fujimycin Hecoria Prograf Protopic TACROLIMUS Tacforius Tacrolimus tacrolimus
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|
| Has_Target | ||
| label |
Tacrolimus
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|
| Legacy Concept Name |
Tacrolimus
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| NCI_Drug_Dictionary_ID |
42009
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| NSC Number |
717865
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| PDQ_Closed_Trial_Search_ID |
42009
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| PDQ_Open_Trial_Search_ID |
42009
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|
| Preferred_Name |
Tacrolimus
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|
| prefixIRI |
Thesaurus:C1311
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0085149
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| subClassOf |
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