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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1298
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1298
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|---|---|
| Preferred Name | O-Chloroacetylcarbamoylfumagillol |
| Definitions |
A synthetic analog of fumagillin, an antibiotic isolated from the fungus Aspergillus fumigatus fresenius with antineoplastic activity. TNP-470 binds to and irreversibly inactivates methionine aminopeptidase-2 (MetAP2), resulting in endothelial cell cycle arrest late in the G1 phase and inhibition of tumor angiogenesis. This agent may also induce the p53 pathway, thereby stimulating the production of cyclin-dependent kinase inhibitor p21 and inhibiting angiogenesis. (NCI04)
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| Synonyms |
(3R,4S,5S,6R)-5-Methoxy-4- [(2R,3R)-2-methyl-3-(3-methyl-2-butenyl) -oxiranyl]-1-oxaspiro [2,5] oct-6-yl(chloroacetyl) Carbamate
5-methoxy-4-(2-methyl-3-(3-methyl-2-butenyl)oxiranyl)-1-oxaspiro(2,5)oct-6-yl(chloroacetyl) carbamate
[3R-[3alpha,4alpha(2R*,3R*),5beta,6beta]]-5-Methoxy-4-[2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl (chloroacetyl)carbamate
O-Chloroacetylcarbamoylfumagillol
AGM-1470
TNP-470
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
O-Chloroacetylcarbamoylfumagillol
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|---|---|
| Maps_To |
O-Chloroacetylcarbamoylfumagillol
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| Legacy Concept Name |
TNP-470
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| NCI_Drug_Dictionary_ID |
41725
|
| Is_Value_For_GDC_Property | |
| PDQ_Closed_Trial_Search_ID |
41725
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| Preferred_Name |
O-Chloroacetylcarbamoylfumagillol
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| prefixIRI |
Thesaurus:C1298
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| DEFINITION |
A synthetic analog of fumagillin, an antibiotic isolated from the fungus Aspergillus fumigatus fresenius with antineoplastic activity. TNP-470 binds to and irreversibly inactivates methionine aminopeptidase-2 (MetAP2), resulting in endothelial cell cycle arrest late in the G1 phase and inhibition of tumor angiogenesis. This agent may also induce the p53 pathway, thereby stimulating the production of cyclin-dependent kinase inhibitor p21 and inhibiting angiogenesis. (NCI04)
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| UMLS_CUI |
C0081489
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| code |
C1298
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| subClassOf | |
| NSC Number |
642492
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| type | |
| CAS_Registry |
129298-91-5
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| FULL_SYN |
(3R,4S,5S,6R)-5-Methoxy-4- [(2R,3R)-2-methyl-3-(3-methyl-2-butenyl) -oxiranyl]-1-oxaspiro [2,5] oct-6-yl(chloroacetyl) Carbamate
5-methoxy-4-(2-methyl-3-(3-methyl-2-butenyl)oxiranyl)-1-oxaspiro(2,5)oct-6-yl(chloroacetyl) carbamate
[3R-[3alpha,4alpha(2R*,3R*),5beta,6beta]]-5-Methoxy-4-[2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl (chloroacetyl)carbamate
O-Chloroacetylcarbamoylfumagillol
AGM-1470
TNP-470
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| FDA_UNII_Code |
X47GR46481
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| ALT_DEFINITION |
A substance being studied in the treatment of cancer. It may prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent.
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| PDQ_Open_Trial_Search_ID |
41725
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| Contributing_Source |
FDA
GDC
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| Concept_In_Subset |
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