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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C126712
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C126712
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|---|---|
| Preferred Name | Fluoroquinolone Antibiotic |
| Definitions |
Any quinolone antibiotic with a fluorine (F) atom attached to the quinolone structure, with broad-spectrum antibacterial activity. Fluoroquinolones diffuse through the bacterial cell wall and act by inhibiting bacterial topoisomerase II, DNA gyrase and/or bacterial topoisomerase IV, which are enzymes involved in bacterial DNA replication. This prevents DNA replication and leads to a blockage of bacterial cell proliferation.
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| Synonyms |
Fluoroquinolone
Fluoroquinolones
Fluoroquinolone Antibiotic
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Fluoroquinolone Antibiotic
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|---|---|
| Preferred_Name |
Fluoroquinolone Antibiotic
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| Display_Name |
Fluoroquinolone Antibiotic
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| Semantic_Type |
Chemical Viewed Functionally
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| prefixIRI |
Thesaurus:C126712
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| DEFINITION |
Any quinolone antibiotic with a fluorine (F) atom attached to the quinolone structure, with broad-spectrum antibacterial activity. Fluoroquinolones diffuse through the bacterial cell wall and act by inhibiting bacterial topoisomerase II, DNA gyrase and/or bacterial topoisomerase IV, which are enzymes involved in bacterial DNA replication. This prevents DNA replication and leads to a blockage of bacterial cell proliferation.
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| UMLS_CUI |
C0949665
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| code |
C126712
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| subClassOf | |
| type | |
| FULL_SYN |
Fluoroquinolone
Fluoroquinolones
Fluoroquinolone Antibiotic
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| Contributing_Source |
CTRP
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| Concept_In_Subset |
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