National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Samarium Sm-153 Lexidronam Pentasodium
Synonyms

Samarium Sm-153 EDTMP Pentasodium

Samarium Sm 153 Lexidronam Pentasodium

Samarium-153 EDTMP Pentasodium

Sm 153 Lexidronam Pentasodium

samarium Sm 153 lexidronam pentasodium

SAMARIUM SM-153 LEXIDRONAM PENTASODIUM

Samarium Sm-153 Lexidronam Pentasodium

Quadramet
Definitions

The pentasodium salt of samarium Sm 153 lexidronam, a therapeutic agent consisting of a medium energy beta- and gamma-emitting radioisotope, samarium Sm 153, and a teraphosphonate chelator, ethylenediaminetetramethylene phosphonic acid (EDTMP). The chelator moiety of samarium Sm 153 lexidronam associates with hydroxyapatite crystals concentrated in areas of bone turnover, thereby selectively delivering samarium Sm 153-mediated cytotoxic radiation to osteoblastic bone metastases.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1220
ALT_DEFINITION

A drug used to treat pain caused by bone cancer and other cancers that have spread to the bones. Samarium Sm 153 lexidronam pentasodium is a type of radiopharmaceutical.
CAS_Registry

160369-78-8
Chemical_Formula

C6H12N2O12P4.5Na.Sm
code

C1220
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

CTRP

FDA
DEFINITION

The pentasodium salt of samarium Sm 153 lexidronam, a therapeutic agent consisting of a medium energy beta- and gamma-emitting radioisotope, samarium Sm 153, and a teraphosphonate chelator, ethylenediaminetetramethylene phosphonic acid (EDTMP). The chelator moiety of samarium Sm 153 lexidronam associates with hydroxyapatite crystals concentrated in areas of bone turnover, thereby selectively delivering samarium Sm 153-mediated cytotoxic radiation to osteoblastic bone metastases.
Display_Name

Samarium Sm-153 Lexidronam Pentasodium
FDA_UNII_Code

7389YR3OOV
FULL_SYN

Samarium Sm-153 EDTMP Pentasodium

Samarium Sm 153 Lexidronam Pentasodium

Samarium-153 EDTMP Pentasodium

Sm 153 Lexidronam Pentasodium

samarium Sm 153 lexidronam pentasodium

SAMARIUM SM-153 LEXIDRONAM PENTASODIUM

Samarium Sm-153 Lexidronam Pentasodium

Quadramet
Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C152291
label

Samarium Sm-153 Lexidronam Pentasodium
Legacy Concept Name

Sm_153_Lexidronam_Pentasodium
NCI_Drug_Dictionary_ID

42245
NSC Number

741196
PDQ_Closed_Trial_Search_ID

42245
PDQ_Open_Trial_Search_ID

42245
Preferred_Name

Samarium Sm-153 Lexidronam Pentasodium
prefixIRI

Thesaurus:C1220
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0772051
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2124
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