National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Ingenol Mebutate Gel
Synonyms

PEP-005 Topical Gel

Ingenol Mebutate Gel

Ingenol-3-angelate Gel

PEP005 Gel

Picato
Definitions

A topical, aqueous gel formulation containing the mebutate salt form of ingenol, a selective small-molecule activator of protein kinase C (PKC) that is isolated from the sap of Euphorbia species, with potential antineoplastic activity. Upon topical application of the ingenol mebutate gel, ingenol activates various PKC isoforms, which induces apoptosis in certain tumor cells, including myeloid leukemia cells, melanoma cells, and basal cell carcinoma cells. The PKC family consists of signaling isoenzymes that regulate many cell processes, including proliferation, differentiation, and apoptosis.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118776
code

C118776
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537
Contributing_Source

GDC
DEFINITION

A topical, aqueous gel formulation containing the mebutate salt form of ingenol, a selective small-molecule activator of protein kinase C (PKC) that is isolated from the sap of Euphorbia species, with potential antineoplastic activity. Upon topical application of the ingenol mebutate gel, ingenol activates various PKC isoforms, which induces apoptosis in certain tumor cells, including myeloid leukemia cells, melanoma cells, and basal cell carcinoma cells. The PKC family consists of signaling isoenzymes that regulate many cell processes, including proliferation, differentiation, and apoptosis.
FULL_SYN

PEP-005 Topical Gel

Ingenol Mebutate Gel

Ingenol-3-angelate Gel

PEP005 Gel

Picato
Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909
label

Ingenol Mebutate Gel
Maps_To

Ingenol Mebutate Gel
NCI_Drug_Dictionary_ID

766480
PDQ_Closed_Trial_Search_ID

766480
PDQ_Open_Trial_Search_ID

766480
Preferred_Name

Ingenol Mebutate Gel
prefixIRI

Thesaurus:C118776
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C3257744
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C129839
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