loading...| Preferred Name | Itraconazole | |
| Synonyms |
Oriconazole (+-)-1-sec-Butyl-4-(p-(4-(p-(((2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-delta(sup 2)-1,2,4-triazolin-5-one itraconazole Itraconazole ITRACONAZOLE Lozanoc R 51,211 Sporanox |
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| Definitions |
A synthetic triazole agent with antimycotic properties. Formulated for both topical and systemic use, itraconazole preferentially inhibits fungal cytochrome P450 enzymes, resulting in a decrease in fungal ergosterol synthesis. Because of its low toxicity profile, this agent can be used for long-term maintenance treatment of chronic fungal infections. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1138 |
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| Accepted_Therapeutic_Use_For |
Fungal Infections |
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| ALT_DEFINITION |
A drug used to prevent or treat fungal infections. It belongs to the family of drugs called antifungal agents. |
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| CAS_Registry |
84625-61-6 |
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| CHEBI_ID |
CHEBI:6076 |
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| Chemical_Formula |
C35H38Cl2N8O4 |
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| code |
C1138 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
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| Contributing_Source |
CTRP FDA GDC HemOnc |
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| DEFINITION |
A synthetic triazole agent with antimycotic properties. Formulated for both topical and systemic use, itraconazole preferentially inhibits fungal cytochrome P450 enzymes, resulting in a decrease in fungal ergosterol synthesis. Because of its low toxicity profile, this agent can be used for long-term maintenance treatment of chronic fungal infections. (NCI04) |
|
| Display_Name |
Itraconazole |
|
| FDA_UNII_Code |
304NUG5GF4 |
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| FULL_SYN |
Oriconazole (+-)-1-sec-Butyl-4-(p-(4-(p-(((2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-delta(sup 2)-1,2,4-triazolin-5-one itraconazole Itraconazole ITRACONAZOLE Lozanoc R 51,211 Sporanox |
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| Is_Value_For_GDC_Property | ||
| label |
Itraconazole |
|
| Legacy Concept Name |
Itraconazole |
|
| Maps_To |
Itraconazole |
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| NCI_Drug_Dictionary_ID |
39106 |
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| PDQ_Closed_Trial_Search_ID |
39106 |
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| PDQ_Open_Trial_Search_ID |
39106 |
|
| Preferred_Name |
Itraconazole |
|
| prefixIRI |
Thesaurus:C1138 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0064113 |
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| subClassOf |