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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C112881
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C112881
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|---|---|
| Preferred Name | Islet Amyloid Polypeptide |
| Definitions |
Islet amyloid polypeptide (89 aa, ~10 kDa) is encoded by the human IAPP gene. This protein plays a role in the regulation of glucose metabolism.
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| Synonyms |
Insulinoma Amyloid Peptide
Islet Amyloid Polypeptide
Diabetes-Associated Peptide
Amylin
DAP
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Islet Amyloid Polypeptide
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|---|---|
| DesignNote |
The mature islet amyloid polypeptide protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates. Homodimerization may be the first step of amyloid formation. (UniProt)
Islet amyloid polypeptide is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas. (UniProt)
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| Preferred_Name |
Islet Amyloid Polypeptide
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| OMIM_Number |
147940
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Hormone
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| prefixIRI |
Thesaurus:C112881
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| DEFINITION |
Islet amyloid polypeptide (89 aa, ~10 kDa) is encoded by the human IAPP gene. This protein plays a role in the regulation of glucose metabolism.
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| UMLS_CUI |
C0063684
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| code |
C112881
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| Swiss_Prot |
P10997
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| subClassOf | |
| type | |
| FULL_SYN |
Insulinoma Amyloid Peptide
Islet Amyloid Polypeptide
Diabetes-Associated Peptide
Amylin
DAP
|
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