Link to this page
National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
Jump to:
| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1128
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1128
|
|---|---|
| Preferred Name | Leflunomide |
| Definitions |
A derivative of isoxazole used for its immunosuppressive and anti-inflammatory properties. As a prodrug, leflunomide is converted to an active metabolite, A77 1726, which blocks dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis, thereby preventing the expansion of activated T lymphocytes. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC), thereby inhibiting cell proliferation. (NCI04)
|
| Synonyms |
4-Isoxazolecarboxamide, 5-Methyl-N-(4-(trifluoromethyl)phenyl)-
LEFLUNOMIDE
leflunomide
Leflunomide
Arava
SU101
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Leflunomide
|
|---|---|
| Maps_To |
Leflunomide
|
| Legacy Concept Name |
Leflunomide
|
| CHEBI_ID |
CHEBI:6402
|
| NCI_Drug_Dictionary_ID |
42253
|
| Is_Value_For_GDC_Property | |
| PDQ_Closed_Trial_Search_ID |
42253
|
| Preferred_Name |
Leflunomide
|
| Display_Name |
Leflunomide
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| prefixIRI |
Thesaurus:C1128
|
| DEFINITION |
A derivative of isoxazole used for its immunosuppressive and anti-inflammatory properties. As a prodrug, leflunomide is converted to an active metabolite, A77 1726, which blocks dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis, thereby preventing the expansion of activated T lymphocytes. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC), thereby inhibiting cell proliferation. (NCI04)
|
| UMLS_CUI |
C0063041
|
| code |
C1128
|
| Chemical_Formula |
C12H9F3N2O2
|
| subClassOf | |
| NSC Number |
677411
|
| type | |
| CAS_Registry |
75706-12-6
|
| FULL_SYN |
4-Isoxazolecarboxamide, 5-Methyl-N-(4-(trifluoromethyl)phenyl)-
LEFLUNOMIDE
leflunomide
Leflunomide
Arava
SU101
See more
See less
|
| FDA_UNII_Code |
G162GK9U4W
|
| ALT_DEFINITION |
An anticancer drug that works by inhibiting a cancer cell growth factor.
|
| PDQ_Open_Trial_Search_ID |
42253
|
| Contributing_Source |
CTRP
FDA
GDC
|
| Concept_In_Subset |
See more
See less
|
| Has_Target |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |