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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1099
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1099
|
|---|---|
| Preferred Name | Finasteride |
| Definitions |
A synthetic 4-azasteroid compound. Finasteride competitively binds to and inhibits steroid type II 5-alpha-reductase in the prostate gland, liver, and skin, thereby interfering with the enzymatic conversion of testosterone to 5-dihydrotestosterone (DHT) and reducing serum DHT levels. The reduction in serum DHT levels results in diminished stimulation of androgen receptors in the nuclei of prostate cells and, so, diminished prostate cell proliferation.
|
| Synonyms |
Chibro-Proscar
Finasteride
FINASTERIDE
finasteride
(5alpha,17beta)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
Finastid
MK 906
Pro-Cure
Propecia
Propeshia
Proscar
Prostide
Urprosan
See more
See less
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Finasteride
|
|---|---|
| Legacy Concept Name |
Finasteride
|
| CHEBI_ID |
CHEBI:5062
|
| NCI_Drug_Dictionary_ID |
41096
|
| PDQ_Closed_Trial_Search_ID |
41096
|
| Preferred_Name |
Finasteride
|
| Display_Name |
Finasteride
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| prefixIRI |
Thesaurus:C1099
|
| DEFINITION |
A synthetic 4-azasteroid compound. Finasteride competitively binds to and inhibits steroid type II 5-alpha-reductase in the prostate gland, liver, and skin, thereby interfering with the enzymatic conversion of testosterone to 5-dihydrotestosterone (DHT) and reducing serum DHT levels. The reduction in serum DHT levels results in diminished stimulation of androgen receptors in the nuclei of prostate cells and, so, diminished prostate cell proliferation.
|
| UMLS_CUI |
C0060389
|
| code |
C1099
|
| Chemical_Formula |
C23H36N2O2
|
| subClassOf | |
| type | |
| CAS_Registry |
98319-26-7
|
| FULL_SYN |
Chibro-Proscar
Finasteride
FINASTERIDE
finasteride
(5alpha,17beta)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
Finastid
MK 906
Pro-Cure
Propecia
Propeshia
Proscar
Prostide
Urprosan
See more
See less
|
| FDA_UNII_Code |
57GNO57U7G
|
| ALT_DEFINITION |
A drug used to reduce the amount of male hormone (testosterone) produced by the body.
|
| PDQ_Open_Trial_Search_ID |
41096
|
| Contributing_Source |
CTRP
FDA
HemOnc
|
| Concept_In_Subset | |
| Has_Target |
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