loading...| Preferred Name | Exemestane | |
| Synonyms |
6-Methyleneandrosta-1,4-diene-3,17-dione Aromasin EXEMESTANE Exemestane FCE-24304 exemestane |
|
| Definitions |
An irreversible steroidal aromatase inhibitor, with antiestrogen and antineoplastic activities. Upon oral administration, exemestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the peripheral aromatization of androgens, including androstenedione and testosterone, to estrogens. This lowers estrogen levels in the blood circulation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1097 |
|
| Accepted_Therapeutic_Use_For |
Estrogen Receptor-Positive Early Breast Cancer; early and advanced-stage breast cancer |
|
| ALT_DEFINITION |
A drug used to treat advanced breast cancer and to prevent recurrent breast cancer in postmenopausal women who have already been treated with tamoxifen. It is also being studied in the treatment of other types of cancer. Aromasin causes a decrease in the amount of estrogen made by the body. It is a type of aromatase inhibitor. |
|
| CAS_Registry |
107868-30-4 |
|
| CHEBI_ID |
CHEBI:4953 |
|
| Chemical_Formula |
C20H24O2 |
|
| code |
C1097 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc |
|
| DEFINITION |
An irreversible steroidal aromatase inhibitor, with antiestrogen and antineoplastic activities. Upon oral administration, exemestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the peripheral aromatization of androgens, including androstenedione and testosterone, to estrogens. This lowers estrogen levels in the blood circulation. |
|
| Display_Name |
Exemestane |
|
| FDA_UNII_Code |
NY22HMQ4BX |
|
| FULL_SYN |
6-Methyleneandrosta-1,4-diene-3,17-dione Aromasin EXEMESTANE Exemestane FCE-24304 exemestane |
|
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Exemestane |
|
| Legacy Concept Name |
Exemestane |
|
| Maps_To |
Exemestane |
|
| NCI_Drug_Dictionary_ID |
42297 |
|
| NSC Number |
713563 |
|
| PDQ_Closed_Trial_Search_ID |
42297 |
|
| PDQ_Open_Trial_Search_ID |
42297 |
|
| Preferred_Name |
Exemestane |
|
| prefixIRI |
Thesaurus:C1097 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0851344 |
|
| subClassOf |