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National Cancer Institute Thesaurus
Last uploaded:
July 2, 2026
| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C474
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C474
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|---|---|
| Preferred Name | Epirubicin Hydrochloride |
| Definitions |
The hydrochloride salt of the 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.
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| Synonyms |
(8S-cis)-10-((3-Amino-2,3,6-trideoxy-beta-L-arabino-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione Hydrochloride
Epirubicin Hydrochloride
epirubicin hydrochloride
EPIRUBICIN HYDROCHLORIDE
Pharmorubicin PFS
3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranoside Hydrochloride
Ellence
IMI-28
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label | Epirubicin Hydrochloride
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|---|---|
| prefixIRI | Thesaurus:C474
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| code | C474
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| DEFINITION | The hydrochloride salt of the 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.
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| ALT_DEFINITION | A drug used together with other drugs to treat early breast cancer that has spread to lymph nodes. It is also being studied in the treatment of other types of cancer. Ellence is a type of anthracycline antibiotic.
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| Is_Value_For_GDC_Property | |
| Legacy Concept Name | Epirubicin
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| PDQ_Open_Trial_Search_ID | 39232
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| Contributing_Source |
CTRP
FDA
GDC
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| Accepted_Therapeutic_Use_For | Breast cancer
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| NCI_Drug_Dictionary_ID | 39232
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| FULL_SYN | (8S-cis)-10-((3-Amino-2,3,6-trideoxy-beta-L-arabino-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione Hydrochloride
Epirubicin Hydrochloride
epirubicin hydrochloride
EPIRUBICIN HYDROCHLORIDE
Pharmorubicin PFS
3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranoside Hydrochloride
Ellence
IMI-28
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| Chemical_Formula | C27H29NO11.HCl
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| UMLS_CUI | C0700582
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| Maps_To | Epirubicin Hydrochloride
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| FDA_UNII_Code | 22966TX7J5
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| NSC Number | 256942
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| Preferred_Name | Epirubicin Hydrochloride
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| type | |
| subClassOf | |
| Display_Name | Epirubicin Hydrochloride
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| PDQ_Closed_Trial_Search_ID | 39232
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| Has_Free_Acid_Or_Base_Form | |
| Has_Target | |
| CAS_Registry | 56390-09-1
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| Concept_In_Subset |
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Antibiotic
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