loading...| Preferred Name |
Methotrexate |
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| Synonyms |
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| ID |
http://scai.fraunhofer.de/MSOntology#Methotrexate |
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| Context |
Drug :DBA000556 |
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| isDefinedBy |
An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. |
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| prefixIRI |
MSOntology:Methotrexate |
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| prefLabel |
Methotrexate |
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| Reference | ||
| Synonym |
Amethopterin Novatrex Medsatrexate Fauldexato Emtexate Methotrexate Methylaminopterin Folex Methotrexate MTX Methoblastin Mexate-AQ Trixilem Maxtrex Methotrexate LPF Emthexate Metrotex Texate Lumexon Brimexate Rheumatrex Folex PFS Metex Farmitrexat Abitrexate 4-Amino-4-deoxy-10-methylpteroyl-L-glutamic Acid Emthexat Mexate Alpha-Methopterin 4-Amino-10-methylfolic Acid Metotrexato Trexeron Ledertrexate Tremetex Methotrexatum Lantarel MTX - Methotrexate |
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| subClassOf |
http://scai.fraunhofer.de/MSOntology#Disease_modifying_drugs |