loading...| Preferred Name |
obsolete idiopathic and/or familial pulmonary arterial hypertension |
|
| Synonyms |
PPH1 pulmonary hypertension, primary, 1 idiopathic and/or familial pulmonary arterial hypertension IFPAH pulmonary hypertension, primary, type 1 |
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| Definitions |
OBSOLETE. Idiopathic and/or familial pulmonary arterial hypertension (IFPAH) is a form or pulmonary arterial hypertension (PAH, see his term) characterized by elevated pulmonary arterial resistance leading to right heart failure; it is progressive and potentially fatal. About 75% of heritable pulmonary arterial hypertension (HPAH) have an identified mutation. HPAH has been linked to mutations in BMPR2 in 75% of cases; other genes implicated in HPAH include ACVR1, BMPR1, CAV1, ENG and SMAD9 and CBLN2. (However, the majority of patients carrying an HPAH mutation do not develop PAH). Idiopathic pulmonary arterial hypertension (IFPAH) refers to those cases of pulmonary arterial hypertension in which etiology remains unknown. |
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| ID |
http://purl.obolibrary.org/obo/MONDO_0008347 |
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| Obsolete |
true |
|
| database_cross_reference |
GARD:16531 Orphanet:422 |
|
| definition |
OBSOLETE. Idiopathic and/or familial pulmonary arterial hypertension (IFPAH) is a form or pulmonary arterial hypertension (PAH, see his term) characterized by elevated pulmonary arterial resistance leading to right heart failure; it is progressive and potentially fatal. About 75% of heritable pulmonary arterial hypertension (HPAH) have an identified mutation. HPAH has been linked to mutations in BMPR2 in 75% of cases; other genes implicated in HPAH include ACVR1, BMPR1, CAV1, ENG and SMAD9 and CBLN2. (However, the majority of patients carrying an HPAH mutation do not develop PAH). Idiopathic pulmonary arterial hypertension (IFPAH) refers to those cases of pulmonary arterial hypertension in which etiology remains unknown. |
|
| deprecated |
true |
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| exactMatch | ||
| has_exact_synonym |
pulmonary hypertension, primary, type 1 IFPAH idiopathic and/or familial pulmonary arterial hypertension |
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| has_related_synonym |
pulmonary hypertension, primary, 1 PPH1 |
|
| IAO_0000231 | ||
| IAO_0000233 |
https://github.com/monarch-initiative/mondo/issues/6740 |
|
| id |
MONDO:0008347 |
|
| in_subset |
http://purl.obolibrary.org/obo/mondo#ordo_disease |
|
| label |
obsolete idiopathic and/or familial pulmonary arterial hypertension |
|
| notation |
MONDO:0008347 |
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| prefLabel |
obsolete idiopathic and/or familial pulmonary arterial hypertension |
|
| excluded subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/MONDO_0008347 | EFO | SAME_URI | |
| http://purl.obolibrary.org/obo/MONDO_0008347 | DOVES | SAME_URI | |
| http://purl.obolibrary.org/obo/MONDO_0008347 | KTAO | SAME_URI | |
| http://purl.obolibrary.org/obo/MONDO_0008347 | EFO | LOOM | |
| http://www.orpha.net/ORDO/Orphanet_422 | EFO | LOOM |