Myocardial Infarction Ontology

Last uploaded: December 18, 2024
Id http://www.semanticweb.org/admin/ontologies/2022/7/MIO:03068
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:03068
Preferred Name

rofecoxib

Definitions
A synthetic, nonsteroidal derivative of phenyl-furanone with antiinflammatory, antipyretic and analgesic properties and potential antineoplastic properties. Rofecoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. COX-related metabolic pathways may represent key regulators of cell proliferation and neo-angiogenesis. Some epithelial tumor cell types overexpress pro-angiogenic COX-2. [url:http://purl.obolibrary.org/obo/NCIT_C1832]
Synonyms
4-[4'-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
MK 966
vioxx
Type http://www.w3.org/2002/07/owl#Class
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