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Myocardial Infarction Ontology
Last uploaded:
February 21, 2023
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| Preferred Name | perindopril | |
| Synonyms |
(2S,3aS,7aS)-1-((S)-N-((S)-1-carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester S-9490 |
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| Definitions |
A non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, perindopril is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue. [url:http://purl.obolibrary.org/obo/NCIT_C72910] |
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| ID |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02624 |
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| definition |
A non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, perindopril is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue. [url:http://purl.obolibrary.org/obo/NCIT_C72910]
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| label |
perindopril
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| MIO_ID |
MIO:02624
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| prefLabel |
perindopril
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| reference |
NCIT:C72910 UMLS:C0136123 CHEBI:8024
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| synonyms |
(2S,3aS,7aS)-1-((S)-N-((S)-1-carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester S-9490
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| subClassOf |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02115 |
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