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Myocardial Infarction Ontology
| Preferred Name | fosinopril | |
| Synonyms |
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| Definitions |
A phosphinic acid-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As an ester prodrug, fosinopril is hydrolysed by esterases to its active metabolite fosinoprilat. Fosinoprilat specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II, resulting in diminished vasopressor activity. In addition, angiotensin II-mediated aldosterone secretion by adrenal cortex is decreased, which results in a decrease of sodium retention and an increase in water outflow. [url:http://purl.obolibrary.org/obo/NCIT_C65761] |
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| ID |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02622 |
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| definition |
A phosphinic acid-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As an ester prodrug, fosinopril is hydrolysed by esterases to its active metabolite fosinoprilat. Fosinoprilat specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II, resulting in diminished vasopressor activity. In addition, angiotensin II-mediated aldosterone secretion by adrenal cortex is decreased, which results in a decrease of sodium retention and an increase in water outflow. [url:http://purl.obolibrary.org/obo/NCIT_C65761]
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| label |
fosinopril
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| MIO_ID |
MIO:02622
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| prefLabel |
fosinopril
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| reference |
NCIT:C65761 UMLS:C0118168 CHEBI:5163
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| subClassOf |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02115 |
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