Preferred Name |
leflunomide |
|
Synonyms |
4-Isoxazolecarboxamide, 5-Methyl-N-(4-(trifluoromethyl)phenyl)- SU101 arava |
|
Definitions |
A derivative of isoxazole used for its immunosuppressive and anti-inflammatory properties. As a prodrug, leflunomide is converted to an active metabolite, A77 1726, which blocks dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis, thereby preventing the expansion of activated T lymphocytes. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC), thereby inhibiting cell proliferation. [url:http://purl.obolibrary.org/obo/NCIT_C1128] |
|
ID |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02536 |
|
definition |
A derivative of isoxazole used for its immunosuppressive and anti-inflammatory properties. As a prodrug, leflunomide is converted to an active metabolite, A77 1726, which blocks dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis, thereby preventing the expansion of activated T lymphocytes. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC), thereby inhibiting cell proliferation. [url:http://purl.obolibrary.org/obo/NCIT_C1128] |
|
label |
leflunomide |
|
MIO_ID |
MIO:02536 |
|
prefLabel |
leflunomide |
|
reference |
NCIT:C1128 |
|
synonyms |
4-Isoxazolecarboxamide, 5-Methyl-N-(4-(trifluoromethyl)phenyl)- SU101 arava |
|
subClassOf |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:01924 |