Myocardial Infarction Ontology

Last uploaded: February 21, 2023
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Preferred Name

complement C4
Synonyms

Complement Component-4

C4
Definitions

An early component of the classical and mannose binding lectin (MBL) complement activation pathways. C4 is consumed by proteolysis upon activation of the classical and MBL pathways, but not the alternative pathway. C4 levels are generally low in active immune complex diseases mediated by classical or MBL activation, but not alternative activation, with the canonical example being systemic lupus erythematosus. [url:http://purl.obolibrary.org/obo/NCIT_C70618]
ID

http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02398
definition

An early component of the classical and mannose binding lectin (MBL) complement activation pathways. C4 is consumed by proteolysis upon activation of the classical and MBL pathways, but not the alternative pathway. C4 levels are generally low in active immune complex diseases mediated by classical or MBL activation, but not alternative activation, with the canonical example being systemic lupus erythematosus. [url:http://purl.obolibrary.org/obo/NCIT_C70618]
label

complement C4
MIO_ID

MIO:02398
prefLabel

complement C4
reference

UMLS:C0577608

NCIT:C80177

NCIT:C70618
synonyms

Complement Component-4

C4
subClassOf

http://www.semanticweb.org/admin/ontologies/2022/7/MIO:01370
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