loading...| Preferred Name | high mobility group protein B1 | |
| Synonyms |
nonhistone chromosomal protein HGM1 high-mobility group box 1 sulfoglucuronyl carbohydrate binding protein high-mobility group (nonhistone chromosomal) protein 1 HMG 1 HMG-1 HMG1 HMG3 HMGB1 SBP-1 amphoterin |
|
| Definitions |
High mobility group protein B1 (215 aa, ~25 kDa) is encoded by the human HMGB1 gene. This protein is involved in the regulation of both chromatin structure and DNA topology. HMGB1 is a very abundant and conserved 25-kD protein which plays a central role in the stabilization and/or assembly of several nucleoprotein multifunctional complexes through protein-protein interactions. HMGB1 is essential in a variety of DNA-related biological processes, e.g., V(D)J recombination, the initiation of transcription, and DNA repair. HMGB1 binds DNA without sequence specificity, but has a high affinity for bent or distorted DNA, and bend linear DNA. HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. HMGB1 is structured into two DNA-binding HMG-box domains (A and B) plus a long highly acidic C-terminal domain. The individual A and B boxes exhibit many of the structure-specific properties of the whole protein and the acidic tail modulates the affinity of the tandem HMG boxes in HMGB1 for a variety of DNA targets. (PMID 11497996, PMID 11748221) [url:http://purl.obolibrary.org/obo/NCIT_C20328] |
|
| ID |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:01635 |
|
| definition |
High mobility group protein B1 (215 aa, ~25 kDa) is encoded by the human HMGB1 gene. This protein is involved in the regulation of both chromatin structure and DNA topology. HMGB1 is a very abundant and conserved 25-kD protein which plays a central role in the stabilization and/or assembly of several nucleoprotein multifunctional complexes through protein-protein interactions. HMGB1 is essential in a variety of DNA-related biological processes, e.g., V(D)J recombination, the initiation of transcription, and DNA repair. HMGB1 binds DNA without sequence specificity, but has a high affinity for bent or distorted DNA, and bend linear DNA. HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. HMGB1 is structured into two DNA-binding HMG-box domains (A and B) plus a long highly acidic C-terminal domain. The individual A and B boxes exhibit many of the structure-specific properties of the whole protein and the acidic tail modulates the affinity of the tandem HMG boxes in HMGB1 for a variety of DNA targets. (PMID 11497996, PMID 11748221) [url:http://purl.obolibrary.org/obo/NCIT_C20328] |
|
| label |
high mobility group protein B1 |
|
| MIO_ID |
MIO:01635 |
|
| prefLabel |
high mobility group protein B1 |
|
| reference |
NCIT:C20328 PR:P09429 |
|
| synonyms |
nonhistone chromosomal protein HGM1 high-mobility group box 1 sulfoglucuronyl carbohydrate binding protein high-mobility group (nonhistone chromosomal) protein 1 HMG 1 HMG-1 HMG1 HMG3 HMGB1 SBP-1 amphoterin |
|
| subClassOf |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:00716 |