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Molecular Interactions
Last uploaded:
August 6, 2024
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| Id | http://purl.obolibrary.org/obo/MI_0208
http://purl.obolibrary.org/obo/MI_0208
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|---|---|
| Preferred Name | genetic interaction (sensu unexpected) |
| Definitions |
An effect in which two genetic perturbations, when combined, result in a phenotype that does not appear to be merely explained by the superimposition or addition of effects of the original perturbations.
ab (not=) E
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| Synonyms |
Fisher epistasis
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An effect in which two genetic perturbations, when combined, result in a phenotype that does not appear to be merely explained by the superimposition or addition of effects of the original perturbations. ab (not=) E |
|---|---|
| label | genetic interaction (sensu unexpected)
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| prefLabel | genetic interaction (sensu unexpected)
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| notation | MI:0208
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| in_subset | |
| id | MI:0208
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| has_obo_namespace | PSI-MI
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| subClassOf | |
| type | |
| has_exact_synonym | Fisher epistasis
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| isDefinedBy | More generally, a genetic interaction can be defined as the difference between an experimentally measured double-mutant phenotype and an expected double-mutant phenotype, the latter of which is predicted from the combination of the single-mutant effects, assuming the mutations act independently.
A genetic interaction refers to an unexpected phenotype not easily explained by combining the effects of individual genetic variants (7).
A quantitative genetic interaction definition has two components: a quantitative phenotypic measure and a neutrality function that predicts the phenotype of an organism carrying two noninteracting mutations. Interaction is then defined by deviation of a double-mutant organism's phenotype from the expected neutral phenotype.
Two genes A and B 'genetically interact' when the phenotype generated as the result of mutations in both genes (double mutant ab) is unexpectedly not just a combination of the phenotypes of the two single mutants a and b.
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