genetic interaction (sensu unexpected)

Fisher epistasis

An effect in which two genetic perturbations, when combined, result in a phenotype that does not appear to be merely explained by the superimposition or addition of effects of the original perturbations. ab (not=) E

http://purl.obolibrary.org/obo/MI_0208

An effect in which two genetic perturbations, when combined, result in a phenotype that does not appear to be merely explained by the superimposition or addition of effects of the original perturbations. ab (not=) E

Fisher epistasis

PSI-MI

MI:0208

http://purl.obolibrary.org/obo/mi#PSI-MI_slim

More generally, a genetic interaction can be defined as the difference between an experimentally measured double-mutant phenotype and an expected double-mutant phenotype, the latter of which is predicted from the combination of the single-mutant effects, assuming the mutations act independently.

A genetic interaction refers to an unexpected phenotype not easily explained by combining the effects of individual genetic variants (7).

A quantitative genetic interaction definition has two components: a quantitative phenotypic measure and a neutrality function that predicts the phenotype of an organism carrying two noninteracting mutations. Interaction is then defined by deviation of a double-mutant organism's phenotype from the expected neutral phenotype.

Two genes A and B 'genetically interact' when the phenotype generated as the result of mutations in both genes (double mutant ab) is unexpectedly not just a combination of the phenotypes of the two single mutants a and b.

genetic interaction (sensu unexpected)

MI:0208

genetic interaction (sensu unexpected)

http://purl.obolibrary.org/obo/MI_2402

http://purl.obolibrary.org/obo/MI_2402