loading...| Preferred Name | genetic interaction (sensu unexpected) | |
| Synonyms |
Fisher epistasis |
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| Definitions |
An effect in which two genetic perturbations, when combined, result in a phenotype that does not appear to be merely explained by the superimposition or addition of effects of the original perturbations. ab (not=) E |
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| ID |
http://purl.obolibrary.org/obo/MI_0208 |
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| definition |
An effect in which two genetic perturbations, when combined, result in a phenotype that does not appear to be merely explained by the superimposition or addition of effects of the original perturbations. ab (not=) E |
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| has_exact_synonym |
Fisher epistasis |
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| has_obo_namespace |
PSI-MI |
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| id |
MI:0208 |
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| in_subset | ||
| isDefinedBy |
More generally, a genetic interaction can be defined as the difference between an experimentally measured double-mutant phenotype and an expected double-mutant phenotype, the latter of which is predicted from the combination of the single-mutant effects, assuming the mutations act independently. A genetic interaction refers to an unexpected phenotype not easily explained by combining the effects of individual genetic variants (7). A quantitative genetic interaction definition has two components: a quantitative phenotypic measure and a neutrality function that predicts the phenotype of an organism carrying two noninteracting mutations. Interaction is then defined by deviation of a double-mutant organism's phenotype from the expected neutral phenotype. Two genes A and B 'genetically interact' when the phenotype generated as the result of mutations in both genes (double mutant ab) is unexpectedly not just a combination of the phenotypes of the two single mutants a and b. |
|
| label |
genetic interaction (sensu unexpected) |
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| notation |
MI:0208 |
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| prefLabel |
genetic interaction (sensu unexpected) |
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| treeView | ||
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/MI_0208 | CCO | SAME_URI | |
| http://purl.obolibrary.org/obo/MI_0208 | REXO | SAME_URI | |
| http://purl.obolibrary.org/obo/MI_0208 | GEXO | SAME_URI | |
| http://purl.obolibrary.org/obo/MI_0208 | INO | SAME_URI | |
| http://purl.obolibrary.org/obo/MI_0208 | RETO | SAME_URI | |
| http://purl.obolibrary.org/obo/MI_0208 | HINO | SAME_URI |