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Last uploaded: January 31, 2024

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Preferred Name	Valproic Acid
Synonyms	Valproate Calcium
Definitions	A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
ID	http://purl.bioontology.org/ontology/MESH/D014635
altLabel	Valproate Calcium Convulsofin Ergenyl Depakote Calcium Valproate Pentanoic acid, 2-propyl- Vupral Divalproex Sodium Valproate Divalproex Depakine Semisodium Valproate 2-Propylpentanoic Acid Depakene Sodium Valproate Propylisopropylacetic Acid Valproate Sodium Dipropyl Acetate Magnesium Valproate Valproic Acid, Sodium Salt (2:1) 2 Propylpentanoic Acid
AQL	AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR
cui	C0037567 C0700659 C0700658 C0080356 C0700662 C0700661 C0042291 C0524735 C0006724 C0086166 C0886883 C0719751
DC	1
definition	A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
DX	19790101
HN	1991; was VALPROATE 1979-1990; was DIPROPYL ACETATE see under VALERATES 1975-1978
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB	5VOM6GYJ0D Q400352CM2 614OI1Z5WI 56CCK4F86G 644VL95AO6 0
isa	http://purl.bioontology.org/ontology/MESH/D018692 http://purl.bioontology.org/ontology/MESH/D000927 http://purl.bioontology.org/ontology/MESH/D004791 http://purl.bioontology.org/ontology/MESH/D018682
LT	TRD
Machine permutation	1991; was VALPROATE 1979-1990; was DIPROPYL ACETATE see under VALERATES 1975-1978
Mapped from	http://purl.bioontology.org/ontology/MESH/C079546 http://purl.bioontology.org/ontology/MESH/C079547 http://purl.bioontology.org/ontology/MESH/C073602 http://purl.bioontology.org/ontology/MESH/C113682 http://purl.bioontology.org/ontology/MESH/C420746 http://purl.bioontology.org/ontology/MESH/C072835 http://purl.bioontology.org/ontology/MESH/C041285 http://purl.bioontology.org/ontology/MESH/C032265 http://purl.bioontology.org/ontology/MESH/C032266 http://purl.bioontology.org/ontology/MESH/C032264 http://purl.bioontology.org/ontology/MESH/C556631 http://purl.bioontology.org/ontology/MESH/C108761 http://purl.bioontology.org/ontology/MESH/C000620177 http://purl.bioontology.org/ontology/MESH/C091207 http://purl.bioontology.org/ontology/MESH/C091208 http://purl.bioontology.org/ontology/MESH/C529310 http://purl.bioontology.org/ontology/MESH/C059137 http://purl.bioontology.org/ontology/MESH/C096095 http://purl.bioontology.org/ontology/MESH/C449752 http://purl.bioontology.org/ontology/MESH/C027089 http://purl.bioontology.org/ontology/MESH/C027298 http://purl.bioontology.org/ontology/MESH/C093456 http://purl.bioontology.org/ontology/MESH/C434604 http://purl.bioontology.org/ontology/MESH/C088775 http://purl.bioontology.org/ontology/MESH/C088776 http://purl.bioontology.org/ontology/MESH/C115083 http://purl.bioontology.org/ontology/MESH/C071295 http://purl.bioontology.org/ontology/MESH/C570212 http://purl.bioontology.org/ontology/MESH/C546746 http://purl.bioontology.org/ontology/MESH/C104864 http://purl.bioontology.org/ontology/MESH/C471110 http://purl.bioontology.org/ontology/MESH/C117226 http://purl.bioontology.org/ontology/MESH/C117228 http://purl.bioontology.org/ontology/MESH/C513635 http://purl.bioontology.org/ontology/MESH/C513636 http://purl.bioontology.org/ontology/MESH/C529309 http://purl.bioontology.org/ontology/MESH/C584451 http://purl.bioontology.org/ontology/MESH/C004651 http://purl.bioontology.org/ontology/MESH/C109566 http://purl.bioontology.org/ontology/MESH/C109567 http://purl.bioontology.org/ontology/MESH/C479801 http://purl.bioontology.org/ontology/MESH/C452022 http://purl.bioontology.org/ontology/MESH/C050477 http://purl.bioontology.org/ontology/MESH/C536525
MDA	19741111
MMR	20180619
MN	D02.241.081.944.509.900 D10.251.400.895.593.900
notation	D014635
OL	use VALPROIC ACID to search VALPROATE 1979-90 & DIPROPYL ACETATE 1975-90
PA	D000927 D004791 D018692 D018682
prefLabel	Valproic Acid
RR	5VOM6GYJ0D Q400352CM2 99-66-1 (Valproic Acid) 76584-70-8 (Na salt (2:1)) 56CCK4F86G 644VL95AO6
TERMUI	T359788 T042798 T840355 T042794 T042804 T042797 T042796 T042799 T042801 T042793 T042791 T042800 T042803 T042792 T761055 T042795 T042805 T042806 T042802 T427789
TH	NLM (1996) NLM (1999) NLM (1991) FDA SRS (2014) UNK (19XX) USAN (1978) INN (19XX) NLM (1998) NLM (2014) NLM (2011) USP (19XX) BAN (19XX) USAN (1983)
tui	T109 T121
subClassOf	http://purl.bioontology.org/ontology/MESH/D010421

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/VANDF/4018724	VANDF	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000350047	PDQ	CUI
http://purl.bioontology.org/ontology/RXNORM/40254	RXNORM	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000350047	PDQ	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387080000	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/RXNORM/134422	RXNORM	CUI
http://purl.bioontology.org/ontology/RXNORM/1927	RXNORM	CUI
http://purl.bioontology.org/ontology/MSHFRE/D014635	MSHFRE	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000778070	PDQ	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000778070	PDQ	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387481005	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000178986	NDFRT	CUI
http://purl.bioontology.org/ontology/SNMI/C-61131	SNMI	CUI
http://purl.bioontology.org/ontology/NDDF/001623	NDDF	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000350047	PDQ	CUI
http://purl.bioontology.org/ontology/RCD/dnb..	RCD	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147029	NDFRT	CUI
http://purl.bioontology.org/ontology/MSHFRE/D014635	MSHFRE	CUI
http://purl.bioontology.org/ontology/SCTSPA/387481005	SCTSPA	CUI
http://purl.bioontology.org/ontology/RXNORM/9919	RXNORM	CUI
http://purl.bioontology.org/ontology/RCD/x00Bp	RCD	CUI
http://purl.bioontology.org/ontology/SNMI/C-61130	SNMI	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000350047	PDQ	CUI
http://purl.bioontology.org/ontology/SCTSPA/264325000	SCTSPA	CUI
http://purl.bioontology.org/ontology/RCD/XC0RS	RCD	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/264325000	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/LNC/LP16305-2	LOINC	CUI
http://purl.bioontology.org/ontology/LNC/MTHU005126	LOINC	CUI
http://purl.bioontology.org/ontology/CSP/0562-9957	CRISP	CUI
http://purl.bioontology.org/ontology/MSHFRE/D014635	MSHFRE	CUI
http://purl.bioontology.org/ontology/ATC/N03AG01	ATC	CUI
http://purl.bioontology.org/ontology/SCTSPA/13965000	SCTSPA	CUI
http://purl.bioontology.org/ontology/VANDF/4018723	VANDF	CUI
http://purl.bioontology.org/ontology/SCTSPA/387080000	SCTSPA	CUI
http://purl.bioontology.org/ontology/SNMI/C-61132	SNMI	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000350047	PDQ	CUI
http://purl.bioontology.org/ontology/RXNORM/11118	RXNORM	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147028	NDFRT	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006250	NDFRT	CUI
http://purl.bioontology.org/ontology/VANDF/4022507	VANDF	CUI
http://purl.bioontology.org/ontology/NDDF/001622	NDDF	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/13965000	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/MSHFRE/D014635	MSHFRE	CUI
http://purl.bioontology.org/ontology/RCD/dnh..	RCD	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000020512	NDFRT	CUI
http://purl.bioontology.org/ontology/NDDF/006036	NDDF	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000573418	PDQ	CUI
http://purl.bioontology.org/ontology/MSHFRE/D014635	MSHFRE	CUI
http://purl.bioontology.org/ontology/NDDF/007107	NDDF	CUI
http://purl.bioontology.org/ontology/MSHFRE/D014635	MSHFRE	CUI
http://purl.bioontology.org/ontology/RXNORM/266856	RXNORM	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147033	NDFRT	CUI
http://purl.bioontology.org/ontology/SNMI/C-61133	SNMI	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000179722	NDFRT	CUI
http://purl.bioontology.org/ontology/NDDF/001624	NDDF	CUI
http://purl.bioontology.org/ontology/VANDF/4018728	VANDF	CUI
http://purl.bioontology.org/ontology/SCTSPA/5641004	SCTSPA	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/5641004	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/RXNORM/216459	RXNORM	CUI
http://purl.obolibrary.org/obo/CHEBI_39867	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_39867	FYPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_39867	HOIP	LOOM
http://purl.obolibrary.org/obo/CHEBI_39867	CHEBI	LOOM
http://www.case.edu/EpilepsyOntology.owl#ValproicAcid	EPSO	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387080000	SNOMEDCT	LOOM
http://www.case.edu/EpSO.owl#ValproicAcid	MEPO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0042291	OCHV	LOOM
http://purl.obolibrary.org/obo/CHEBI_39867	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_39867	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_39867	OBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_39867	DINTO	LOOM
http://purl.obolibrary.org/obo/CHEBI_39867	COVID-19	LOOM
http://purl.obolibrary.org/obo/CHEBI_39867	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_39867	TXPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_39867	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_39867	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_39867	CIDO	LOOM
http://purl.obolibrary.org/obo/CHEBI_39867	NIFSTD	LOOM
http://purl.obolibrary.org/obo/OMIT_0015469	OMIT	LOOM
http://purl.bioontology.org/ontology/ATC/N03AG01	ATC	LOOM
http://purl.bioontology.org/ontology/VANDF/4018723	VANDF	LOOM
http://stirdf.jst.go.jp/id/200907057055574563	IOBC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D014635	RH-MESH	LOOM
http://doe-generated-ontology.com/OntoAD#C0042291	ONTOAD	LOOM
http://purl.jp/bio/4/id/200906053586959002	IOBC	LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Valproic_Acid	APAONTO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12885	OCHV	LOOM
http://purl.bioontology.org/ontology/SNMI/C-61132	SNMI	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000350047	PDQ	LOOM
http://purl.bioontology.org/ontology/RXNORM/11118	RXNORM	LOOM
http://purl.obolibrary.org/obo/NCIT_C29536	BERO	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147028	NDFRT	LOOM
http://www.semanticweb.org/cjf/ontologies/2022/8/NeuralReprogrammingOntology(NRO)#Valproic_acid	NRO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.081.944.509.900	RH-MESH	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016455	PMAPP-PMO	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29536	NCIT	LOOM
https://go.drugbank.com/drugs/DB00313	MDM	LOOM
http://purl.bioontology.org/ontology/NDDF/001622	NDDF	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D10.251.400.895.593.900	RH-MESH	LOOM
http://purl.bioontology.org/ontology/RCD/dnh..	RCD	LOOM
http://www.drugbank.ca/drugs/DB00313	FTC	LOOM
http://www.semanticweb.org/ftuha/ontologies/2021/5/FRMO-01untitled-ontology-175/Valproic_Acid	FRMO	LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Valproic_acid	STMSO	LOOM
http://purl.obolibrary.org/obo/MESH_D014635	BERO	LOOM