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Medical Subject Headings
Last uploaded:
March 22, 2026
| Id | http://purl.bioontology.org/ontology/MESH/D064466
http://purl.bioontology.org/ontology/MESH/D064466
|
|---|---|
| Preferred Name | Solute Carrier Family 12, Member 1 |
| Definitions |
Na-K-Cl transporter in the ASCENDING LIMB OF LOOP OF HENLE. It mediates active reabsorption of sodium chloride and is inhibited by LOOP DIURETICS such as FUROSEMIDE; and BUMETANIDE. Mutations in the gene encoding SLC12A1 are associated with a BARTTER SYNDROME.
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| Synonyms |
Kidney Specific Na K Cl Symporter
Kidney-Specific Na-K-Cl Symporter
Symporter, Kidney-Specific Na-K-Cl
Na-K-Cl Symporter, Kidney-Specific
Bumetanide-Sensitive Sodium-(Potassium)-Chloride Cotransporter 2
SLC12A1 Protein
Protein, SLC12A1
NKCC2 Protein
BSC1 Transport Protein
SLC12A1 Cotransporter
Cotransporter, SLC12A1
Cotransporter, NKCC2
NKCC2 Cotransporter
Transport Protein, BSC1
Protein, NKCC2
Protein, BSC1 Transport
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|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Na-K-Cl transporter in the ASCENDING LIMB OF LOOP OF HENLE. It mediates active reabsorption of sodium chloride and is inhibited by LOOP DIURETICS such as FUROSEMIDE; and BUMETANIDE. Mutations in the gene encoding SLC12A1 are associated with a BARTTER SYNDROME. |
|---|---|
| altLabel |
Kidney Specific Na K Cl Symporter
Kidney-Specific Na-K-Cl Symporter
Symporter, Kidney-Specific Na-K-Cl
Na-K-Cl Symporter, Kidney-Specific
Bumetanide-Sensitive Sodium-(Potassium)-Chloride Cotransporter 2
SLC12A1 Protein
Protein, SLC12A1
NKCC2 Protein
BSC1 Transport Protein
SLC12A1 Cotransporter
Cotransporter, SLC12A1
Cotransporter, NKCC2
NKCC2 Cotransporter
Transport Protein, BSC1
Protein, NKCC2
Protein, BSC1 Transport
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|
| prefLabel | Solute Carrier Family 12, Member 1
|
| Machine permutation | 2014; was indexed under SYMPORTER 2001-2013
|
| HN | 2014
|
| Mapped from | |
| type | |
| tui |
T116
T123
|
| TERMUI |
T838289
T838292
T838291
T838294
T838295
T838290
T838293
T838296
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| TH | NLM (2014)
|
| MMR | 20230405
|
| notation | D064466
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| Inverse of RO | |
| Semantic type UMLS property | |
| Inverse of AQ |
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| FX | D001477
|
| DX | 20140101
|
| cui | C3658231
|
| DC | 1
|
| MN |
D12.776.543.585.450.625.750.500
D12.776.543.585.937.875.500
D12.776.157.530.450.625.875.750.500
D12.776.157.530.937.750.500
|
| AQL | AD AE AG AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
|
| Inverse of RB | 0
|
| MDA | 20130307
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |