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Medical Subject Headings
Last uploaded:
March 22, 2026
| Id | http://purl.bioontology.org/ontology/MESH/D064029
http://purl.bioontology.org/ontology/MESH/D064029
|
|---|---|
| Preferred Name | Peroxisomal Multifunctional Protein-2 |
| Definitions |
A dimeric protein found in liver peroxisomes that plays an important role in FATTY ACID metabolism and steroid metabolism. The dimer is formed by cleavage of a single protein precursor and contains an enoyl-CoA hydratase-2 domain and a second domain that displays (S)-3-hydroxyacyl-CoA dehydrogenase and 17-beta-estradiol dehydrogenase activities. The enzyme is stereospecific with regards to arrangement of the substrate double bonds and position of the 3-hydroxy group of the reaction intermediate. It is complemented by PEROXISOMAL BIFUNCTIONAL ENZYME, which has the opposite reaction stereospecificity.
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| Synonyms |
3-alpha,7-alpha,12-alpha-Trihydroxy-5-beta-Cholest-24-enoyl-CoA Hydratase
17 beta Hydroxysteroid Dehydrogenase 4
Multifunctional Protein-2, Peroxisomal
Peroxisomal Multifunctional Enzyme Type 2
Dehydrogenase 4, 17-beta-Hydroxysteroid
Peroxisomal Multifunctional Protein 2
17-beta-Hydroxysteroid Dehydrogenase 4
4, 17-beta-Hydroxysteroid Dehydrogenase
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A dimeric protein found in liver peroxisomes that plays an important role in FATTY ACID metabolism and steroid metabolism. The dimer is formed by cleavage of a single protein precursor and contains an enoyl-CoA hydratase-2 domain and a second domain that displays (S)-3-hydroxyacyl-CoA dehydrogenase and 17-beta-estradiol dehydrogenase activities. The enzyme is stereospecific with regards to arrangement of the substrate double bonds and position of the 3-hydroxy group of the reaction intermediate. It is complemented by PEROXISOMAL BIFUNCTIONAL ENZYME, which has the opposite reaction stereospecificity. |
|---|---|
| altLabel |
3-alpha,7-alpha,12-alpha-Trihydroxy-5-beta-Cholest-24-enoyl-CoA Hydratase
17 beta Hydroxysteroid Dehydrogenase 4
Multifunctional Protein-2, Peroxisomal
Peroxisomal Multifunctional Enzyme Type 2
Dehydrogenase 4, 17-beta-Hydroxysteroid
Peroxisomal Multifunctional Protein 2
17-beta-Hydroxysteroid Dehydrogenase 4
4, 17-beta-Hydroxysteroid Dehydrogenase
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| prefLabel | Peroxisomal Multifunctional Protein-2
|
| Machine permutation | 2014
|
| HN | 2014
|
| Mapped from | |
| type | |
| tui |
T116
T126
|
| TERMUI |
T833634
T833633
T833632
T833570
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| TH | NLM (2014)
|
| MMR | 20140101
|
| notation | D064029
|
| Semantic type UMLS property | |
| RR |
EC 1.1.1.-
EC 4.2.1.119
|
| Inverse of AQ |
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|
| DX | 20140101
|
| cui | C3539825
|
| DC | 1
|
| MN |
D08.811.641.812
D08.811.682.047.820.150.926
D08.811.520.241.300.275.500
D08.811.682.047.436.375.640
|
| AQL | AD AE AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
|
| Inverse of RB | EC 4.2.1.107
|
| MDA | 20121128
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |