Medical Subject Headings

Last uploaded: March 22, 2026

Id	http://purl.bioontology.org/ontology/MESH/D054707 http://purl.bioontology.org/ontology/MESH/D054707
Preferred Name	Cyclic Nucleotide Phosphodiesterases, Type 6
Definitions	A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in the outer segment PHOTORECEPTOR CELLS of the RETINA. It is comprised of two catalytic subunits, referred to as alpha and beta, that form a dimer. In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme.
Synonyms	Cyclic Nucleotide Phosphodiesterases, Type 6, alpha Subunit cGMP-PDE gamma Subunit cGMP Phosphodiesterase delta Subunit Cyclic Nucleotide Phosphodiesterases, Type 6, beta Subunit Retinal Phosphodiesterase, beta Subunit PDE6 beta Subunit gamma Subunit, cGMP-PDE Phosphodiesterases, PDE6 alpha Subunit, PDE6 delta Subunit, PDE6 Rod cGMP Phosphodiesterase, beta Subunit PDE6 alpha Subunit cGMP PDE gamma Subunit PDE6 Phosphodiesterases beta Subunit PDE6 Cyclic Nucleotide Phosphodiesterases, Type 6, delta Subunit alpha Subunit PDE6 Phosphodiesterase Type 6 PDE6, alpha Subunit beta Subunit, PDE6 Phosphodiesterase 6, Retinal PDE6, beta Subunit Phosphodiesterase 6 Cyclic Nucleotide Phosphodiesterases, Type 6, gamma Subunit Retinal Phosphodiesterase, delta Subunit PDE6, delta Subunit Retinal Phosphodiesterase 6 Retinal Phosphodiesterase, alpha Subunit delta Subunit PDE6 gamma Subunit, cGMP Phosphodiesterase PDE6 delta Subunit See more See less
Type	http://www.w3.org/2002/07/owl#Class

definition	A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in the outer segment PHOTORECEPTOR CELLS of the RETINA. It is comprised of two catalytic subunits, referred to as alpha and beta, that form a dimer. In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme.
altLabel	Cyclic Nucleotide Phosphodiesterases, Type 6, alpha Subunit cGMP-PDE gamma Subunit cGMP Phosphodiesterase delta Subunit Cyclic Nucleotide Phosphodiesterases, Type 6, beta Subunit Retinal Phosphodiesterase, beta Subunit PDE6 beta Subunit gamma Subunit, cGMP-PDE Phosphodiesterases, PDE6 alpha Subunit, PDE6 delta Subunit, PDE6 Rod cGMP Phosphodiesterase, beta Subunit PDE6 alpha Subunit cGMP PDE gamma Subunit PDE6 Phosphodiesterases beta Subunit PDE6 Cyclic Nucleotide Phosphodiesterases, Type 6, delta Subunit alpha Subunit PDE6 Phosphodiesterase Type 6 PDE6, alpha Subunit beta Subunit, PDE6 Phosphodiesterase 6, Retinal PDE6, beta Subunit Phosphodiesterase 6 Cyclic Nucleotide Phosphodiesterases, Type 6, gamma Subunit Retinal Phosphodiesterase, delta Subunit PDE6, delta Subunit Retinal Phosphodiesterase 6 Retinal Phosphodiesterase, alpha Subunit delta Subunit PDE6 gamma Subunit, cGMP Phosphodiesterase PDE6 delta Subunit See more See less
prefLabel	Cyclic Nucleotide Phosphodiesterases, Type 6
Machine permutation	2008; PHOSPHODIESTERASE 6 (now CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 6) was indexed under PHOSPHORIC ACID DIESTERASES 2001-2007; CGMP PHOSPHODIESTERASE DELTA SUBUNIT was indexed under 3,5,'-CYCLIC-GMP PHOSPHODIESTERASE 2004-2007
HN	2008(2001)
Mapped from	http://purl.bioontology.org/ontology/MESH/C000723885 http://purl.bioontology.org/ontology/MESH/C096885 http://purl.bioontology.org/ontology/MESH/C586891 http://purl.bioontology.org/ontology/MESH/C517432 http://purl.bioontology.org/ontology/MESH/C517433 http://purl.bioontology.org/ontology/MESH/C517439 http://purl.bioontology.org/ontology/MESH/C517438 http://purl.bioontology.org/ontology/MESH/C517431 http://purl.bioontology.org/ontology/MESH/C410522 http://purl.bioontology.org/ontology/MESH/C498747 http://purl.bioontology.org/ontology/MESH/C517444 See more See less
type	http://www.w3.org/2002/07/owl#Class
tui	T116 T126
TERMUI	T692323 T298878 T601007 T320865 T692401 T320864 T692324 T320863 T298879 T437601 T692183 T574678 T296691 T601006 T692187 T296693 T692185 T692322 T320861 T692186 T296692 T692325 See more See less
TH	NLM (2008)
MMR	20210521
notation	D054707
Semantic type UMLS property	http://purl.bioontology.org/ontology/STY/T126 http://purl.bioontology.org/ontology/STY/T116
RR	EC 3.1.4.35 EC 3.1.4.17
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528 See more See less
DX	20080101
cui	C0530494 C0532449 C0675395 C0964364 C1956022
DC	1
MN	D12.776.476.009.750 D08.811.277.352.640.155.750 D08.811.277.352.640.150.600 D12.776.476.008.600
AQL	AD AE AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
Inverse of RB	EC 3.1.4.- EC 3.1.4.35
MDA	20070223
subClassOf	http://purl.bioontology.org/ontology/MESH/D015106 http://purl.bioontology.org/ontology/MESH/D015105

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