Medical Subject Headings

Last uploaded: January 16, 2025

Preferred Name	Perforin
Synonyms	Pore-Forming Protein, Lymphocyte Cytolysin Lymphocyte Pore-Forming Protein Perforin 1 Lymphocyte Pore Forming Protein
Definitions	A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.
ID	http://purl.bioontology.org/ontology/MESH/D054353
altLabel	Pore-Forming Protein, Lymphocyte Cytolysin Lymphocyte Pore-Forming Protein Perforin 1 Lymphocyte Pore Forming Protein
AQL	AD AE AG AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
cui	C0070410
DC	1
definition	A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.
DX	20080101
HN	2008
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB	126465-35-8
isa	http://purl.bioontology.org/ontology/MESH/D003603
Machine permutation	2008; PERFORIN was indexed under MEMBRANE GLYCOPROTEINS & PORE FORMING CYTOTOXIC PROTEINS 1985-2007
Mapped from	http://purl.bioontology.org/ontology/MESH/C510468 http://purl.bioontology.org/ontology/MESH/C510467 http://purl.bioontology.org/ontology/MESH/C000592415 http://purl.bioontology.org/ontology/MESH/C534951 http://purl.bioontology.org/ontology/MESH/C000592414
MDA	20070709
MMR	20080708
MN	D12.776.543.695.875
notation	D054353
PA	D003603
prefLabel	Perforin
TERMUI	T602609 T163733 T163737 T602608
TH	NLM (2008)
tui	T116 T123
subClassOf	http://purl.bioontology.org/ontology/MESH/D052899

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/MSHFRE/D054353	MSHFRE	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000178600	NDFRT	CUI
http://purl.bioontology.org/ontology/LNC/MTHU015708	LOINC	CUI
http://purl.bioontology.org/ontology/SCTSPA/707736000	SCTSPA	CUI
http://purl.bioontology.org/ontology/CSP/2948-5030	CRISP	CUI
http://purl.bioontology.org/ontology/CSP/2948-5030	CRISP	CUI
http://purl.bioontology.org/ontology/LNC/LP33048-7	LOINC	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/707736000	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/CSP/2447-5100	CRISP	CUI
http://purl.bioontology.org/ontology/CSP/2447-5100	CRISP	CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D054353	RH-MESH	LOOM
http://purl.obolibrary.org/obo/IDOMAL_0000396	IDOMAL	LOOM
http://purl.obolibrary.org/obo/IDOMAL_0000396	IDODEN	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14596	OCHV	LOOM
http://purl.obolibrary.org/obo/OMIT_0025762	OMIT	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU015708	LOINC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.543.695.875	RH-MESH	LOOM
http://purl.bioontology.org/ontology/LNC/LP33048-7	LOINC	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/707736000	SNOMEDCT	LOOM
http://purl.obolibrary.org/obo/MESH_D054353	BERO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0070410	OCHV	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00023524	PMAPP-PMO	LOOM
http://id.nlm.nih.gov/mesh/D054353	MDM	LOOM
http://purl.jp/bio/4/id/200906029662576276	IOBC	LOOM